L-368,899 HYDROCHLORIDE
|
|
- CAS号:
- 160312-62-9
- 英文名:
- 1-((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2,2,1]HEPTAN-1(S)-YL)METHYLSULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE HYDROCHLORIDE
- 英文别名:
- L-368;899 hydrochloride;L-368,899 HYDROCHLORIDE;1-((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2,2,1]HEPTAN-1(S)-YL)METHYLSULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE HYDROCHLORIDE;(S)-2-amino-N-((1S,2S,4R)-7,7-dimethyl-1-(((4-(o-tolyl)piperazin-1-yl)sulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide hydrochloride
- 中文名:
- L-368,899 HYDROCHLORIDE
- 中文别名:
- 化合物 T11794;L-368,899盐酸盐
- CBNumber:
- CB6302164
- 分子式:
- C26H42N4O5S2
- 分子量:
- 554.77
- MOL File:
- Mol file
|
|
|
L-368,899 HYDROCHLORIDE化学性质
-
储存条件:
-
−20°C
-
|
-
溶解度:
-
H2O: 20 mg/mL, soluble
-
|
-
形态:
-
powder
-
|
-
颜色:
-
white
-
|
L-368,899 HYDROCHLORIDE性质、用途与生产工艺
L-368,899 hydrochloride 是一种有效的,选择性的,可口服的,非肽类催产素受体 oxytocin receptor 拮抗剂,对大鼠和人子宫 oxytocin receptor 的 IC50 值分别为 8.9 nM 和 26 nM,为抗早产剂。
IC50: 8.9 nM (rat uterus oxytocin receptor), 26 nM (human uterus oxytocin receptor)
L-368,899 hydrochloride is a potent, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC
50
s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. L-368,899 is less active on VP receptor in human liver and kidney, rat liver and kidney (IC
50
, 510 nM, 960 nM, 890 nM, 2400 nM, respectively).
L-368,899 exhibits similar pharmacokinetics in rats and dogs. After a single iv. injection, L-368,899 had a t
1/2
of 2 hr in both species. Additionally, L-368,899 has a plasma clearance between 23 and 36 ml/min/kg in rats or dogs. L-368,899 exhibits V
dss
values of 2.0 and 2.6 liters/kg and 3.4 to 4.9 liters/kg for dogs, respectively.
L-368,899 is orally available. In the rat, at the 5 mg/kg dose, the oral bioavailabilities are 14% and 18% for female and male rats, respectively. Additionally, the oral bioavailabilities are 17% and 41% for female and male rats, respectively at the dosage of 25 mg/kg.
L-368,899 HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-108677 | L-368,899 HYDROCHLORIDE L-368,899 hydrochloride | 160312-62-9 | 1mg | 1000元 |
2024/08/19 | HY-108677 | L-368,899 HYDROCHLORIDE L-368,899 hydrochloride | 160312-62-9 | 5mg | 1900元 |
L-368,899 HYDROCHLORIDE
生产厂家
160312-62-9, L-368,899 HYDROCHLORIDE 相关搜索:
- 抑制剂
- L-368,899盐酸盐
- 化合物 T11794
- 160312-62-9
- L-368
- 899 hydrochloride
- (S)-2-amino-N-((1S,2S,4R)-7,7-dimethyl-1-(((4-(o-tolyl)piperazin-1-yl)sulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide hydrochloride
- L-368,899 HYDROCHLORIDE
- 1-((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2,2,1]HEPTAN-1(S)-YL)METHYLSULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE HYDROCHLORIDE