AR-R17779 HYDROCHLORIDE
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- CAS号:
- 178419-42-6
- 英文名:
- AR-R 17779 hydrochloride
- 英文别名:
- AR-R 17779 hydrochloride, >=98%;AR-R17779 Hydrochloride >=97% (HPLC);(3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride
- 中文名:
- AR-R17779 HYDROCHLORIDE
- 中文别名:
- 化合物 T21857;AR-R17779 盐酸盐;化合物 AR-R 17779 HYDROCHLORIDE
- CBNumber:
- CB63037151
- 分子式:
- C9H15ClN2O2
- 分子量:
- 218.68
- MOL File:
- 178419-42-6.mol
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AR-R17779 HYDROCHLORIDE化学性质
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储存条件:
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-20°C
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溶解度:
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<10.93mg/ml in DMSO; <21.87mg/ml in H2O
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形态:
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powder
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颜色:
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white to beige
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旋光性 (optical activity):
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[α]/D -59 to -69°, c = 1.0 in methanol
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AR-R17779 HYDROCHLORIDE性质、用途与生产工艺
AR-R17779 hydrochloride 是一种有效和选择性的 nAChR 全激动剂，对 α7 和 α4β2 亚型的 Ki 直分别为 92 和 16000 nM。AR-R17779 hydrochloride 可以改善大鼠的学习和记忆能力。AR-R17779 hydrochloride 也具有抗焦虑活性。AR-R17779 hydrochloride 可通过激活抗炎胆碱能（迷走神经）途径减轻炎症。
AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine for the α7 nicotinic receptor.
AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages.
AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) ameliorates arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction.
AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats.
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Animal Model:
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Male DBA/1 mice (8-10 weeks) were subjected to unilateral cervical vagotomy or sham surgery, after which arthritis was induced with type II collagen
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Dosage:
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1, 2.5, 5 mg/kg
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Administration:
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I.p. twice daily from day 20 until day 26
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Result:
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Ameliorated arthritis and delayed onset of disease.
Reduced erosive disease, cartilage degradation and synovial inflammation.
Reduced TNFα levels in plasma and synovial tissue.
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AR-R17779 HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
AR-R17779 HYDROCHLORIDE
生产厂家
178419-42-6, AR-R17779 HYDROCHLORIDE 相关搜索:
- 抑制剂
- C9H14N2O2HCl
- 化合物 AR-R 17779 HYDROCHLORIDE
- AR-R17779 盐酸盐
- 化合物 T21857
- 178419-42-6
- AR-R17779 Hydrochloride >=97% (HPLC)
- (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride
- AR-R 17779 hydrochloride, >=98%