ML241 (hydrochloride)
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- CAS号:
- 2070015-13-1
- 英文名:
- ML241 (hydrochloride)
- 英文别名:
- ML241 (hydrochloride);ML-241,Inhibitor,p97,Cdc48,inhibit,ML241 hydrochloride,ML 241,ML-241 hydrochloride,VCP,ML241
- 中文名:
- ML241 (hydrochloride)
- 中文别名:
- 盐酸ML241;优选]ML241 HYDROCHLORIDE;化合物ML241 HYDROCHLORIDE;P97ATPASE抑制剂(ML241 HYDROCHLORIDE)
- CBNumber:
- CB63122930
- 分子式:
- C23H25ClN4O
- 分子量:
- 408.93
- MOL File:
- 2070015-13-1.mol
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ML241 (hydrochloride)化学性质
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溶解度:
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≥40.9 mg/mL in DMSO; insoluble in H2O; ≥48.7 mg/mL in EtOH
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形态:
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solid
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颜色:
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White to off-white
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ML241 (hydrochloride)性质、用途与生产工艺
ML241 hydrochloride 是一种 p97 的有效选择性抑制剂，对 p97 ATPase 和 UbG76V–GFP 的IC50值分别为0.11 μM和3.5 μM。
| Target | Value |
p97 ATPase
(Cell-free assay)
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0.11 μM
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Ub
(Cell-free assay)
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3.5 μM
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ML241 hydrochloride is a potent p97 inhibitor, inhibiting p97 ATPase with IC
50
values of 100 nM. ML241 inhibits p97 competitively with respect to ATP with a K
i
values of 0.35 μM. ML241 (20 μM) shows no obvious inhibition of the appr 170 kinases tested. ML241 stabilizes Ub
G76V
-GFP with IC
50
of 3.5 μM. ML241 is cytotoxic to HCT15 and SW403 cells, with GI
50
s of 53 and 33 μM after treatment for 24 h, and 13 and 12 μM after treatment for 72 h, respectively.
ML241 (hydrochloride)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-19797A | ML241 (hydrochloride)
ML241 hydrochloride | 2070015-13-1 | 5mg | 600元 |
| 2024/08/19 | HY-19797A | ML241 (hydrochloride)
ML241 hydrochloride | 2070015-13-1 | 10mM * 1mLin DMSO | 880元 |
ML241 (hydrochloride)
生产厂家
2070015-13-1, ML241 (hydrochloride) 相关搜索:
- 药靶配体
- 细胞生物学试剂
- 盐酸ML241
- 优选]ML241 HYDROCHLORIDE
- 化合物ML241 HYDROCHLORIDE
- P97ATPASE抑制剂(ML241 HYDROCHLORIDE)
- 2070015-13-1
- ML-241,Inhibitor,p97,Cdc48,inhibit,ML241 hydrochloride,ML 241,ML-241 hydrochloride,VCP,ML241
- ML241 (hydrochloride)