501698-03-9
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- CAS号:
- 501698-03-9
- 英文名:
- GDP366
- 英文别名:
- GDP366;GDP366;GDP-366;GDP 366;GDP-366,Survivin,GDP 366,inhibit,GDP366,Inhibitor;1-(4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-3-(m-tolyl)urea;Urea, N-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N'-(3-methylphenyl)-
- 中文名:
- 501698-03-9
- 中文别名:
- 化合物GDP366;化合物 T11383;1-(4-(4-氨基噻吩并[2,3-D]嘧啶-5-基)苯基)-3-(间甲苯基)脲
- CBNumber:
- CB63339657
- 分子式:
- C20H17N5OS
- 分子量:
- 375.45
- MOL File:
- 501698-03-9.mol
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501698-03-9化学性质
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熔点:
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227-228 °C(Solv: ethanol (64-17-5))
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沸点:
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538.5±50.0 °C(Predicted)
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密度:
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1.423±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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溶解度:
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DMSO:62.5(Max Conc. mg/mL);166.47(Max Conc. mM)
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形态:
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Solid
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酸度系数(pKa):
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14.22±0.70(Predicted)
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颜色:
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Light yellow to yellow
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501698-03-9性质、用途与生产工艺
GDP366 是 survivin 和 Op18 的双重抑制剂，抑制癌细胞生长，诱导细胞衰老和有丝分裂突变。
GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity.
501698-03-9
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-U00177 | 501698-03-9
GDP366 | 501698-03-9 | 5mg | 5500元 |
| 2024/04/30 | HY-U00177 | GDP366 | | 10 mM * 1 mLin DMSO | 6050元 |
501698-03-9, 501698-03-9 相关搜索:
- 抑制剂
- 化合物GDP366
- 化合物 T11383
- 1-(4-(4-氨基噻吩并[2,3-D]嘧啶-5-基)苯基)-3-(间甲苯基)脲
- 501698-03-9
- GDP-366,Survivin,GDP 366,inhibit,GDP366,Inhibitor
- 1-(4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-3-(m-tolyl)urea
- Urea, N-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N'-(3-methylphenyl)-
- GDP366;GDP-366;GDP 366
- GDP366