PFM01
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- CAS号:
- 1558598-41-6
- 英文名:
- PFM01
- 英文别名:
- PFM01;PFM01 >=98% (HPLC);(Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one;(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)-;Inhibitor,derivative,MRE11,PFM-01,NHEJ,Mirin,DSB,endonuclease,N-alkylated,PFM01,PFM 01,inhibit
- 中文名:
- PFM01
- 中文别名:
- 化合物PFM01;PFM 01,MRE11核酸内切酶抑制剂;(Z)-5-(4-羟基亚苄基)-3-异丁基-2-硫代噻唑烷-4-酮
- CBNumber:
- CB64670537
- 分子式:
- C14H15NO2S2
- 分子量:
- 293.4
- MOL File:
- 1558598-41-6.mol
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PFM01化学性质
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沸点:
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435.2±55.0 °C(Predicted)
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密度:
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1.35±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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Soluble in DMSO
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形态:
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powder
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酸度系数(pKa):
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8.59±0.30(Predicted)
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颜色:
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white to beige
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PFM01性质、用途与生产工艺
PFM01 是 N-烷基化的 Mirin 衍生物,是 MRE11 核酸内切酶抑制剂。PFM01 可以通过非同源末端连接 (NHEJ) 和同源重组 (HR) 调节双链断裂修复 (DSBR)。
PFM01 (100 μM) rescues the repair defect in 48BR (WT) and HSC62 (BRCA2-defective) primary cells.
PFM01 (100 μM) diminishes the RAD51 foci formation in 1BR3 (WT) and HSC62 (BRCA2-defective) cells.
PFM01 (100 μM) enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells.
PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells.
PFM01
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上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-116770 | PFM01 | | 1 mg | 250元 |
2024/08/19 | HY-116770 | PFM01 PFM01 | 1558598-41-6 | 5mg | 500元 |
1558598-41-6, PFM01 相关搜索:
- 药靶配体
- PFM 01,MRE11核酸内切酶抑制剂
- 化合物PFM01
- (Z)-5-(4-羟基亚苄基)-3-异丁基-2-硫代噻唑烷-4-酮
- 1558598-41-6
- 4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)-
- Inhibitor,derivative,MRE11,PFM-01,NHEJ,Mirin,DSB,endonuclease,N-alkylated,PFM01,PFM 01,inhibit
- (Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one
- PFM01 >=98% (HPLC)
- (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
- PFM01