N2'-脱乙酰基-N2'-[3-(甲硫基)-1-氧丙基]-五月氨酸
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- CAS号:
- 912569-84-7
- 英文名:
- N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine
- 英文别名:
- S-methyl DM1;Smethyl DM1,S methyl DM1,S-methyl DM-1;N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine;Maytansine, N2'-deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-;N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine (>90%)
- 中文名:
- N2'-脱乙酰基-N2'-[3-(甲硫基)-1-氧丙基]-五月氨酸
- 中文别名:
- 化合物 T12805;N2'-脱乙酰基-N2'-[3-(甲硫基)-1-氧丙基]-五月氨酸
- CBNumber:
- CB64718640
- 分子式:
- C36H50ClN3O10S
- 分子量:
- 752.32
- MOL File:
- 912569-84-7.mol
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N2'-脱乙酰基-N2'-[3-(甲硫基)-1-氧丙基]-五月氨酸化学性质
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熔点:
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>152°C (dec.)
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沸点:
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936.9±65.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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9.82±0.70(Predicted)
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形态:
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Solid
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颜色:
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Off-White to Pale Yellow
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稳定性:
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Hygroscopic
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N2'-脱乙酰基-N2'-[3-(甲硫基)-1-氧丙基]-五月氨酸性质、用途与生产工艺
S-methyl DM1 是一种美登素 (Maytansine) 的硫代甲基衍生物。S-methyl DM1 以 Kd 为 0.93 μM 结合微管蛋白并抑制微管聚合。S-methyl DM1 可以有效抑制微管动态不稳定性，并具有抗癌作用。
S-methyl DM1 is the primary cellular or liver metabolite of antibody-maytansinoid conjugates prepared with thiol-containing maytansinoids DM1.
The half-maximal concentration for inhibition of microtubule assembly for for S-methyl DM1 is 4 μM. At 100 nM S-methyl-DM1 (84%) suppresses dynamic instability more strongly than Maytansine (45%). Tritiated S-methyl-DM1 bound to 37 high-affinity sites per microtubule (K
d
of 0.1 μM).
The concentration dependence curves for the inhibition of cell proliferation by S-methyl DM1 is sigmoidal in shape in MCF7 cells. Minimal inhibition occurred at 200 pM S-methyl DM1, and inhibition is maximal at 3 nM. S-methyl DM1 (IC
50
of 330 pM) is slightly more potent than Maytansine (IC
50
of 710 pM).
S-methyl DM1 induces maxima of 80% accumulation of cells in G2/M as compared with only 30% in controls in MCF7 cells.
N2'-脱乙酰基-N2'-[3-(甲硫基)-1-氧丙基]-五月氨酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-100504 | S-methyl DM1 | | 1 mg | 2500元 |
| 2024/08/19 | HY-100504 | S-methyl DM1 | | 5 mg | 7500元 |
N2'-脱乙酰基-N2'-[3-(甲硫基)-1-氧丙基]-五月氨酸
生产厂家
912569-84-7, N2'-脱乙酰基-N2'-[3-(甲硫基)-1-氧丙基]-五月氨酸 相关搜索:
- 化合物 T12805
- N2'-脱乙酰基-N2'-[3-(甲硫基)-1-氧丙基]-五月氨酸
- 912569-84-7
- Maytansine, N2'-deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-
- Smethyl DM1,S methyl DM1,S-methyl DM-1
- N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine (>90%)
- S-methyl DM1
- N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine