ARL 67156
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- CAS号:
- 1021868-83-6
- 英文名:
- ARL 67156
- 英文别名:
- ARL67156 trisodium salt,ARL-67156 trisodium salt
- 中文名:
- ARL 67156
- 中文别名:
- 化合物 T14320
- CBNumber:
- CB64806541
- 分子式:
- C15H25Br2N5NaO12P3
- 分子量:
- 743.11
- MOL File:
- 1021868-83-6.mol
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ARL 67156化学性质
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储存条件:
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Desiccate at -20°C
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溶解度:
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<15.78mg/ml in H2O
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形态:
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solid
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颜色:
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White
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水溶解性:
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Soluble to 20 mM in water
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ARL 67156性质、用途与生产工艺
ARL67156 trisodium salt 是一种 ecto-ATPase 抑制剂。ARL67156 trisodium salt 是弱的竞争性 NTPDase1 (CD39),NTPDase3 和 NPP1 抑制剂,Ki 分别为 11,18 和 12 μM。ARL67156 trisodium salt 可预防体内主动脉瓣钙化。
Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)
ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes.
Pre-treatment of mice with ARL67156 (2 mg/kg, i.p.), a selective inhibitor of CD39 (CD39i), completely prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP; 100 mg/kg).
Animal Model:
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C57BL/6 mice
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Dosage:
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2 mg/kg
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Administration:
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Pre-treated (i.p.) 1 h before administration of FBP (100 mg/kg)
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Result:
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Completely prevented the increase of serum adenosine concentration induced by FBP.
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ARL 67156
上下游产品信息
上游原料
下游产品
1021868-83-6, ARL 67156 相关搜索:
- 化合物 T14320
- 1021868-83-6
- ARL67156 trisodium salt,ARL-67156 trisodium salt