NB-598
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- CAS号:
- 131060-14-5
- 英文名:
- NB-598
- 英文别名:
- NB 598,NB-598,inhibit,NB598,Inhibitor;(E)-N-(3-([3,3'-bithiophen]-5-ylmethoxy)benzyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine;(E)-N-(3-([3,3'-bithiophen]-5-ylmethoxy)benzyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine;Benzenemethanamine, 3-([3,3'-bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethyl-
- 中文名:
- NB-598
- 中文别名:
- 化合物NB-598;NB598(游离);(E)-N-(3-([3,3'-联噻吩]-5-基甲氧基)苄基)-N-乙基-6,6-二甲基庚-2-烯-4-炔-1-胺;(E)-N-(3-([3,3'-二噻吩]-5-基甲氧基)苄基)-N-乙基-6,6-二甲基庚-2-烯-4-炔-1-胺;(E)-N-(3-([3,3'-二噻吩]-5-基甲氧基)苄基)-N-乙基-6,6-二甲基庚-2-烯-4-炔-1-胺
- CBNumber:
- CB6504005
- 分子式:
- C27H31NOS2
- 分子量:
- 449.67
- MOL File:
- 131060-14-5.mol
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NB-598化学性质
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熔点:
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~60 °C
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沸点:
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530.7±50.0 °C(Predicted)
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密度:
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1.122±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO: 14 mg/mL
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酸度系数(pKa):
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7.04±0.50(Predicted)
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形态:
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solid
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颜色:
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white
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NB-598性质、用途与生产工艺
NB-598 是一种有效的竞争性 squalene epoxidase (SE) 的抑制剂。NB-598 可抑制 cholesterol胆固醇 的生物合成。
| Target | Value |
squalene epoxidase
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cholesterol
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NB598 (10 μM) causes a 36±7% reduction in total cholesterol level of MIN6 cells. NB598 causes a significant decrease in cholesterol by 49±2%, 46±7%, and 48±2% from PM, ER, and SG, respectively. NB598 dose-dependently inhibits insulin secretion under both basal (1 mM glucose) and glucose-stimulated (16.7 mM glucose) conditions. NB598 at concentrations up to 10 μM does not affect peak outward KV currents or the voltage dependence of activation but increases current inactivation. NB-598 (10 μM) inhibits the synthesis of sterol and sterol ester from [
14
C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). In the absence of exogenous liposomal cholesterol, NB-598 reduces ACAT activity by 31%. NB-598 reduces ACAT activity by 22% even in the presence of a 600 PM concentration of liposomal cholesterol. NB-598 suppresses the secretion of cholesterol and triacylglycerol from HepG2 cells into the medium.
NB-598
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | S0338 | NB-598
NB 598 | 131060-14-5 | 5mg | 2275.58元 |
| 2024/08/19 | S0338 | NB 598 | 131060-14-5 | 10mM (1mL in DMSO) | 2694.51元 |
131060-14-5, NB-598 相关搜索:
- (E)-N-(3-([3,3'-联噻吩]-5-基甲氧基)苄基)-N-乙基-6,6-二甲基庚-2-烯-4-炔-1-胺
- (E)-N-(3-([3,3'-二噻吩]-5-基甲氧基)苄基)-N-乙基-6,6-二甲基庚-2-烯-4-炔-1-胺
- (E)-N-(3-([3,3'-二噻吩]-5-基甲氧基)苄基)-N-乙基-6,6-二甲基庚-2-烯-4-炔-1-胺
- 化合物NB-598
- NB598(游离)
- 131060-14-5
- (E)-N-(3-([3,3'-bithiophen]-5-ylmethoxy)benzyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine
- NB 598,NB-598,inhibit,NB598,Inhibitor
- (E)-N-(3-([3,3'-bithiophen]-5-ylmethoxy)benzyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine
- Benzenemethanamine, 3-([3,3'-bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethyl-