MS023 二盐酸盐
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- CAS号:
- 1992047-64-9
- 英文名:
- MS023 dihydrochloride
- 英文别名:
- MS-023 2HCl;MS023 dihydrochloride;N1-[4-(4-Isopropoxy-phenyl)-1H-pyrrol-3-ylmethyl]-N1-methyl-ethane-1,2-diamine dihydrochloride
- 中文名:
- MS023 二盐酸盐
- 中文别名:
- MS-023 HCL(新增分子);化合物 MS023 DIHYDROCHLORIDE
- CBNumber:
- CB65419791
- 分子式:
- C17H26ClN3O
- 分子量:
- 323.87
- MOL File:
- 1992047-64-9.mol
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MS023 二盐酸盐化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: ≥ 150 mg/mL (416.30 mM)
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形态:
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Solid
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颜色:
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Gray to gray purple
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MS023 二盐酸盐性质、用途与生产工艺
MS023 dihydrochloride 是一种有效选择性的，具有细胞活性的人 I 型蛋白精氨酸甲基转移酶 (PRMTs) 抑制剂，对 PRMT1，PRMT3，PRMT4，PRMT6 和 PRMT8 的 IC50 分别为 30，119，83，4 和 5 nM。
IC50: 30 nM (PRMT1), 119 nM (PRMT3), 83 nM (PRMT4), 4 nM (PRMT6), 5 nM (PRMT8)
MS023 (1-1000 nM; 48 hours) inhibits PRMT1 methyltransferase activity in MCF7 cells.
MS023(1-1000 nM; 20 hours) inhibits PRMT6 methyltransferase activity in HEK293 cells.
Western Blot Analysis
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Cell Line:
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MCF7 and HEK293 cells
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Concentration:
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1.4, 4, 12, 37, 111, 333, and 1000 nM
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Incubation Time:
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48 hours for MCF7 cells; 20 hours for HEK293 cells
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Result:
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Treatment potently and concentration-dependently reduced cellular levels of H4R3me2a (IC
50
=9±0.2 nM).
Treatment concentration-dependently reduced the H3R2me2a mark (IC
50
=56±7 nM).
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Administration of MS023 (160 mg/kg, i.p) in combination with PKC412 (100 mg/kg, i.g.) blocks MLL-r acute lymphoblastic leukemia (ALL) propagation by inhibiting maintenance of functional MLL-r ALL-initiating cells.
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Animal Model:
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NOD-scid IL2Rgnull (NSG) mice bearing primary MLL-r ALL cells
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Dosage:
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160 mg/kg
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Administration:
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Intraperitoneal injection; PKC412 (100 mg/kg, i.g.), MS023 (160 mg/kg, i.p), or a combination for 4 weeks
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Result:
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Combinatorial treatment extended survival of leukemic mice relative to single treatments.
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MS023 二盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-19615B | MS023 DIHYDROCHLORIDE
MS023 dihydrochloride | 1992047-64-9 | 2mg | 760元 |
| 2024/04/30 | HY-19615B | MS023 DIHYDROCHLORIDE
MS023 dihydrochloride | 1992047-64-9 | 10mM * 1mLin DMSO | 793元 |
1992047-64-9, MS023 二盐酸盐 相关搜索:
- 生物试剂
- 酶
- 化合物 MS023 DIHYDROCHLORIDE
- MS-023 HCL(新增分子)
- 1992047-64-9
- MS-023 2HCl
- N1-[4-(4-Isopropoxy-phenyl)-1H-pyrrol-3-ylmethyl]-N1-methyl-ethane-1,2-diamine dihydrochloride
- MS023 dihydrochloride