HPPD
The results show that sulcotrione behaves as time-independent reversible inhibitor. Similar results are previously described for natural β-triketones, and for the synthetic β-triketone NTBC. However it is the first time that such behavior is observed using a purified hydroxyphenylpyruvate dioxygenase (HPPD) and a synthetic β-triketone, namely sulcotrione. Inhibition kinetic analysis, performing with 3 hydroxyphenylpyruvate (HPP) and sulcotrione concentrations, show that the apparent K M increasing with sulcotrione concentration. This behavior is consistent with the data present in the literature, describing sulcotrione as a competitive inhibitor of HPPD.
大鼠急性经口LD50>5000mg/kg。兔急性经皮LD50>4000mg/kg。兔皮肤对其吸收率不高，对皮肤无刺激性，对兔眼中度刺激;对豚鼠皮肤强致敏性。大鼠急性吸入LC50 (4h)1.6mg/L。大鼠 NOEL 数据(2y)100mg/L[0.5mg/(kg ·d)]。ADI(EC)0.0004mg/kg[2008];(BfR)0.007mg/kg[2006]。对大鼠和兔无致畸作用，且无基因毒性。