双醋炔诺醇

双醋炔诺醇 MSDS

19-Nor-17a-pregn-4-en-20-yne-3b,17-diol diacetate

双醋炔诺醇性质、用途与生产工艺

生物活性

Ethynodiol diacetate (8080 CB) 是第一批合成的避孕药用孕激素之一。

靶点

Target	Value
Progesterone receptor

体外研究

去甲二氢愈创木酸(NDGA) (< 1.5 μM)在150 μg/mL ethynodiol diacetate处理的人淋巴细胞中可以降低姐妹染色单体的交换率(SCEs)。在S9混合物存在的情况下NDGA处理会减轻ethynodiol diacetate 引起的遗传毒性损伤，这可能是通过对细胞色素P450s的抑制实现的而P450s会阻止ethynodiol diacetate的代谢活化，也可能是由于 NDGA具有清除自由基的功能。在S9混合物存在的情况下， Ethynodiol diacetate (150 μg/mL)会增加人淋巴细胞中姐妹染色单体的交换率(SCEs)和染色体畸变(CAs)频率并能 抑制淋巴细胞增殖。

体内研究

每天6 mg/kg剂量 Ethynodiol diacetate 可以显著增加雌性大鼠尿液中3alpha-hydroxy-5alpha-pregnan-20-one 和A-homo-3-oxa-5alpha-pregnane-4,20-dione的含量，也可以显著增加大鼠脑垂体，肝脏和肾脏的重量 。Norgestrel (75 μg/天)和ethynodiol diacetate (150 μg/天)以及ethinyl estradiol (7.5 μg/天)联用可以降低食蟹猴高密度脂蛋白胆固醇的血浆浓度

双醋炔诺醇 上下游产品信息

上游原料

下游产品

双醋炔诺醇 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/11/08	HY-B1089	双醋炔诺醇 Ethynodiol diacetate	297-76-7	500mg	600元
2024/11/08	HY-B1089	双醋炔诺醇 Ethynodiol diacetate	297-76-7	10mM * 1mLin DMSO	660元

双醋炔诺醇 生产厂家

 

297-76-7, 双醋炔诺醇 相关搜索:

• VUMIDE
• 抑制剂
• 化学试剂
• 药靶配体
• 代谢物
• 原料药
• 医用中间体
• 医药原料
• 医药中间体
• 其它含氧化合物
• 内分泌与激素
• 小分子抑制剂
• 酸炔诺醇
• 双醋炔若醇
• (3S,8R,9S,10R,13S,14S,17R)-17-乙炔基-13-甲基-2,3,6,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊并[A]菲-3,17-二基 二乙酸酯
• 双醋炔诺醇 标准品
• 双醋炔诺醇 USP标准品
• 双醋炔诺醇(CAS号:297-76-7)
• 乙炔二醇二乙酸酯
• 双醋炔诺醇
• 297-76-7
• 4-ESTREN-17α-ETHYNYL-3β, 17β-DIOL DIACETATE
• (3S,8R,9S,10R,13S,14S,17R)-17-Ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diyl diacetate
• ETHYNODIOL DIACETATE /297-76-7
• Ethynodiol diacetate USP/EP/BP
• 19-Norpregn-4-en-20-yne-3,17-diol, diacetate, (3b,17a)-
• acetic acid [(3S,8R,9S,10R,13S,14S,17R)-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] ester
• Ethynodiol Diacetate (200 mg)
• acetic acid [(3S,8R,9S,10R,13S,14S,17R)-17-acetoxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] ester
• [(3S,8R,9S,10R,13S,14S,17R)-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] ethanoate
• [(3S,8R,9S,10R,13S,14S,17R)-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
• Continuin
• CB-8080
• [(3S,8R,9S,10R,13S,14S,17S)-3-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
• 3β,17β-Diacetoxy-17α-ethynyl-4-estrene
• ETHYLNODIOLACETATE
• 19-Nor-17α-pregn-4-en-20-yne-3β,17-diol diacetate
• etynodiol di(acetate)
• Double vinegar ethynodiol
• Etynodiol acetate
• (3β, 17α)-19-Norpregn-4-en-20-yne-3,17-diol diacetate
• 19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-
• 17a-Ethynyl-4-estren-3b,17-diol diacetate
• 8080 C. B.
• 3-beta,17-beta-Diacetoxy-19-nor-17-alpha-pregn-4-en-20-yne
• 3-beta,17-beta-diacetoxy-17-alpha-ethynyl-4-oestrene
• 3-beta, 17-beta-Diacetoxy-17-alpha-ethynyl-4-oestrene
• 19-Norpregn-4-en-20-yne-3,17-diol, diacetate, (3beta,17alpha)-
• 19-nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol,diacetate
• 19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol diacetate
• 19-Nor-17alpha-pregn-4-en-20-yn-3beta,17-diol diacetate
• 17-alpha-ethynylestr-4-ene-3-beta,17-beta-diolacetate
• 4-ESTREN-17-ALPHA-ETHYNYL-3-BETA, 17-BETA-DIOL DIACETATE
• component of Conova
• Cervicundin
• beta-ethynodioldiacetate
• beta-Ethynodiol diacetate
• 8080c.b.