异丙地尔
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- CAS号:
- 83656-38-6
- 英文名:
- ipramidil
- 英文别名:
- C80-1324;ipramidil;N,N'-Bis(1-methylethyl)furazan-3,4-dicarboxamide 2-oxide;3,4-Bis[(isopropylamino)carbonyl]-1,2,5-oxadiazole 2-oxide;1,2,5-Oxadiazole-3,4-dicarboxamide, N3,N4-bis(1-methylethyl)-, 2-oxide
- 中文名:
- 异丙地尔
- 中文别名:
- 异丙地尔;化合物 T13588
- CBNumber:
- CB6918370
- 分子式:
- C10H16N4O4
- 分子量:
- 256.26
- MOL File:
- 83656-38-6.mol
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异丙地尔化学性质
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密度:
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1.38±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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11.92±0.46(Predicted)
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颜色:
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Off-white to light yellow
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异丙地尔性质、用途与生产工艺
Ipramidil (C80-1324) 是一种呋咱环化合物。在离体心脏的冠脉循环中具有显著的扩张活性。
The vasodilator action of Ipramidil (C80-1324) on coronary vessels is more potent than that of GTN and appears to be biphasic. The increase in coronary flow caused by furoxans as well as by glyceryl trinitrate (GTN) is blunted upon coinfusion of the guanylate cyclase inhibitor methylene blue. NO sign of tachyphylaxis of the vasodilator response is seen upon the repeated or continuous (60 min) application of Ipramidil at a concentration of 1 μg/mL,which induces an increase in coronary flow of 67±9% (N=5). Moreover, the vasodilatoreffect of Ipramidil is not different from control when Ipramidil is given after a 60 min preinfusion of 10 μg/mL GTN, i.e. under conditions of nitrate tolerance (P=0.493, N=3). However,when GTN is applied after a 30 min infusion of Ipramidil, its dilator response is significantly diminished (P=0.006, N=3). Unlike GTN, Ipramidil concentration independently increases the spontaneous beating rate of the hearts by 10-30 beats per minute and appeared to have a weak positive inotropic effect.
异丙地尔
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83656-38-6, 异丙地尔 相关搜索:
- C10H16N4O4
- 化合物 T13588
- 异丙地尔
- 83656-38-6
- 1,2,5-Oxadiazole-3,4-dicarboxamide, N3,N4-bis(1-methylethyl)-, 2-oxide
- C80-1324
- N,N'-Bis(1-methylethyl)furazan-3,4-dicarboxamide 2-oxide
- 3,4-Bis[(isopropylamino)carbonyl]-1,2,5-oxadiazole 2-oxide
- ipramidil