8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine

生物活性靶点体外研究体内研究 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine 试剂级价格

$8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine, 279215-43-9, 结构式$

CAS号:: 279215-43-9

英文名:: 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine

英文别名:: NN414;tifenazoxide;NN414 >=98% (HPLC);NN 414 - Tifenazoxide;6-Chloro-3-[[1-methylcyclopropyl]amino]-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide;2H-Thieno[3,2-e]-1,2,4-thiadiazin-3-amine, 6-chloro-N-(1-methylcyclopropyl)-, 1,1-dioxide;8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine

中文名:: 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine

中文别名:: 化合物 T17094;化合物 TIFENAZOXIDE;6-氯-3-[[1-甲基环丙基]氨基]-4H-噻吩并[3,2-E]-1,2,4-噻二嗪1,1-二氧化物

CBNumber:: CB71261289

分子式:: C9H10ClN3O2S2

分子量:: 291.78

MOL File:: 279215-43-9.mol

化学性质安全信息用途价格供应商 12

8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine化学性质

熔点:: 251-252 °C (decomp)(Solv: methanol (67-56-1); water (7732-18-5))

沸点:: 448.0±55.0 °C(Predicted)

密度:: 1.88±0.1 g/cm3(Predicted)

储存条件:: 2-8°C

溶解度:: DMSO: soluble15mg/mL, clear

酸度系数(pKa):: -6.81±0.20(Predicted)

形态:: powder

颜色:: white to beige

安全信息

WGK Germany:	3

8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine性质、用途与生产工艺

生物活性

Tifenazoxide (NN414) 是一种有效的，口服活性的 SUR1/Kir6.2 选择性 KATP 通道开放剂。Tifenazoxide 具有抗糖尿病作用，可以抑制葡萄糖刺激的胰岛素在体内和体外的释放，并对葡萄糖稳态具有有益作用。

Tifenazoxide (NN414) hyperpolarises βTC3 cell membranes, and inhibits insulin release from βTC6, from isolated rat islets and from human islets at least a 100-fold more potent than Diazoxide.
The EC ₅₀ values for Tifenazoxide and diazoxide are 0.45 and 31 µM, respectively in the patch-clamp assay. Tifenazoxide (100 µM) activates Kir6.2/SUR1 channels, but not Kir6.2/SUR2A or Kir6.2/SUR2 channels, expressed in Xenopus oocytes both in whole-cell and inside-out macropatch recordings.
Tifenazoxide is a potent inhibitor of glucose stimulated insulin release from βTC6 cells (IC ₅₀ = 0.15 µM).

体内研究

Tifenazoxide (NN414; 1.5 mg/kg; oral administration; twice daily; for 3 weeks; male VDF Zucker ( fa/fa ) rat) treatment for 3 weeks in VDF rats reduces basal hyperglycemia, improves glucose tolerance, and reduces hyperinsulinemia during an oral glucose tolerance test (OGTT) and improves insulin secretory responsiveness ex vivo.

Animal Model:	Male Vancouver diabetic fatty (VDF) Zucker rat
Dosage:	1.5 mg/kg
Administration:	Oral administration; twice daily; for 3 weeks
Result:	Basal glucose was significantly reduced with the fall averaging 0.64 mM after 3 weeks of treatment.

8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine 上下游产品信息

上游原料

下游产品

8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2025/02/05	HY-119322	8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine Tifenazoxide	279215-43-9	5mg	1750元
2025/02/05	HY-119322	8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine Tifenazoxide	279215-43-9	10mM * 1mLin DMSO	1925元

8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine 生产厂家

全球有 12家供应商 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	美国	14055	65
上海一飞生物科技有限公司	021-65675885 18964387627	info@efebio.com	中国	9806	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	32161	58
安耐吉化学&3A（安徽泽升科技有限公司）	021-58432009 400-005-6266	marketing@energy-chemical.com	中国	44918	58
天津普西唐生物医药科技有限公司	010-60605840 15801484223	psaitong@jm-bio.com	中国	29774	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24644	58
苏州美石生物科技有限公司	1173954148q	meishipharma@126.com	中国	20033	58
江苏艾康生物医药研发有限公司	025-66113011 18112977050	cb5@aikonchem.com	中国	10526	58
銳迪國際科技有限公司	18024082417	market@ubiochem.com	中国	9266	58
杭州摩库生物医药科技有限公司	+86-057181025280; +8617767106207	sales@molcore.com	中国	49734	58

279215-43-9, 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine 相关搜索:

抑制剂
C9H10ClN3O2S2
化合物 TIFENAZOXIDE
6-氯-3-[[1-甲基环丙基]氨基]-4H-噻吩并[3,2-E]-1,2,4-噻二嗪1,1-二氧化物
化合物 T17094
279215-43-9
NN 414 - Tifenazoxide
NN414 >=98% (HPLC)
2H-Thieno[3,2-e]-1,2,4-thiadiazin-3-amine, 6-chloro-N-(1-methylcyclopropyl)-, 1,1-dioxide
NN414
6-Chloro-3-[[1-methylcyclopropyl]amino]-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide
tifenazoxide
8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine