ICI 153110
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- CAS号:
- 87164-90-7
- 英文名:
- ICI 153110
- 英文别名:
- ICI 153110;4,5-Dihydro-6-[(E)-2-(4-pyridinyl)ethenyl]-2H-pyridazin-3-one;3(2H)-Pyridazinone, 4,5-dihydro-6-[(1E)-2-(4-pyridinyl)ethenyl]-
- 中文名:
- ICI 153110
- 中文别名:
- 化合物 T11609
- CBNumber:
- CB71385828
- 分子式:
- C11H11N3O
- 分子量:
- 201.22
- MOL File:
- 87164-90-7.mol
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ICI 153110化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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ICI 153110性质、用途与生产工艺
ICI 153110 是一种口服有效的磷酸二酯酶 (phosphodiesterase) 抑制剂,具有血管舒张和收缩力性质,可用于充血性心力衰竭的相关研究。
ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure. Fourteen animals have died as a direct or indirect consequence of ICI 153110 administration in the high-dose main test and reversibility groups. In the female rat dosed at 10 mg/kg/day ICI 153110 a mild focal arteritis is characterized by a predominantly and diffusely adventitial infiltration of mixed cells and early formation of fibrous tissue. The two rats dosed at 250 mg/kg/day ICI 153110 die prematurely from intratracheal intubation of dosing solution. Arteries from two further animals (dosed at 5 and 250 mg/kg/day ICI 153110) show minimal focal arteritis with medial necrosis, and medial and adventitial inflammation.
ICI 153110
上下游产品信息
上游原料
下游产品
87164-90-7, ICI 153110 相关搜索:
- 化合物 T11609
- 87164-90-7
- 3(2H)-Pyridazinone, 4,5-dihydro-6-[(1E)-2-(4-pyridinyl)ethenyl]-
- 4,5-Dihydro-6-[(E)-2-(4-pyridinyl)ethenyl]-2H-pyridazin-3-one
- ICI 153110