Neoenactin M1
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- CAS号:
- 32886-15-0
- 英文名:
- Neoenactin M1
- 英文别名:
- G-26146;Brn 2394950;Neoenactin M1;L-2-Amino-N-(14-methyl-3,10-dioxopentadecyl)hydracrylohydroxamic acid;(2S)-2-Amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)propanamide;Hydracrylohydroxamic acid, 2-amino-N-(14-methyl-3,10-dioxopentadecyl)-, L-;Propanamide, 2-amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)-, (S)-;Propanamide, 2-amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)-, (2S)-
- 中文名:
- Neoenactin M1
- 中文别名:
- 化合物 T24412
- CBNumber:
- CB72327829
- 分子式:
- C19H36N2O5
- 分子量:
- 372.5
- MOL File:
- 32886-15-0.mol
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Neoenactin M1化学性质
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沸点:
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578.1±60.0 °C(Predicted)
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密度:
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1.094±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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8.46±0.50(Predicted)
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Neoenactin M1性质、用途与生产工艺
Lipoxamycin 是一种抗真菌抗生素，也是一种有效的丝氨酸棕榈酰转移酶 (serine palmitoyltransferase) 抑制剂，IC50 为 21 nM。
Serine palmitoyltransferase
Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the
Candida
species (MIC values, 0.25-16 µg/mL).
Cryptococcus neoformans
is the most sensitive organism, followed by various species of
Candida
. Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays.
Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme.
Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells.
Neoenactin M1
上下游产品信息
上游原料
下游产品
32886-15-0, Neoenactin M1 相关搜索:
- 化合物 T24412
- 32886-15-0
- Propanamide, 2-amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)-, (2S)-
- Propanamide, 2-amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)-, (S)-
- L-2-Amino-N-(14-methyl-3,10-dioxopentadecyl)hydracrylohydroxamic acid
- Hydracrylohydroxamic acid, 2-amino-N-(14-methyl-3,10-dioxopentadecyl)-, L-
- Brn 2394950
- Neoenactin M1
- G-26146
- (2S)-2-Amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)propanamide