化合物 T28256
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- CAS号:
- 145969-30-8
- 英文名:
- OPC-14523
- 英文别名:
- VPI013;VPI 013;VPI-013;OPC-14523;OPC-14523 free base;OPC 14523 free base,OPC14523 free base;1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-methoxy-3,4-dihydro-2-quinolinone;2(1H)-Quinolinone, 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3,4-dihydro-5-methoxy-
- 中文名:
- 化合物 T28256
- 中文别名:
- 化合物 T28256
- CBNumber:
- CB72446504
- 分子式:
- C23H28ClN3O2
- 分子量:
- 413.94
- MOL File:
- 145969-30-8.mol
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化合物 T28256性质、用途与生产工艺
OPC-14523 free base 是一种具有口服活性的 sigma 和 5-HT1A 受体激动剂，对 sigma 受体 (σ1/2 IC50=47/56 nM)、5-HT1A 受体 (IC50=2.3 nM) 和 5-HT 转运体 (IC50=80 nM) 具有高度亲和力。OPC-14523 free base 显示抗抑郁药样活性。
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5-HT
1A
Receptor
2.3 nM (IC
50
)
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sigma 1
47 nM (IC
50
)
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sigma 2
56 nM (IC
50
)
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OPC-14523 free base (0.3-100 mg/kg; p.o.; daily for 0, 2, 4, 7 days) produces a marked antidepressant-like effect in the forced swimming test (FST) with rats and mice without affecting the general locomotor activity.
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Animal Model:
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Wistar strain of rats (140-245 g)
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Dosage:
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0.3-100 mg/kg
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Administration:
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P.o.; daily for 0, 2, 4, 7 days
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Result:
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A single doses of 1 mg/kg and higher of OPC-14523 reduced immobility time in the FST with an ED
50
value of 27 mg/kg. The ED
50
value for OPC-14523 on day 7 was 18 mg/kg.
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Animal Model:
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ICR strain of mice (25-45 g)
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Dosage:
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0.3-100 mg/kg
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Administration:
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P.o.; daily for 0, 2, 4, 7 days
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Result:
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A single oral dose of OPC-14523 produced a marked reduction in immobility time during the FST at oral doses of 1 mg/kg and higher, with an ED
50
value of 20 mg/kg. The potency of OPC-14523 in decreasing immobility time was greater after treatment for seven consecutive days, producing an ED50 value of 2 mg/kg.
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化合物 T28256
上下游产品信息
上游原料
下游产品
145969-30-8, 化合物 T28256 相关搜索:
- 化合物 T28256
- 145969-30-8
- OPC 14523 free base,OPC14523 free base
- VPI-013
- VPI013
- VPI 013
- OPC-14523 free base
- 2(1H)-Quinolinone, 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3,4-dihydro-5-methoxy-
- 1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-methoxy-3,4-dihydro-2-quinolinone
- OPC-14523