网站主页 >> CAS数据库列表 >> 1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE
1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE
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- CAS号:
- 353791-85-2
- 英文名:
- 1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE
- 英文别名:
- J 113863;1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE;CCR,Inhibitor,inhibit,rheumatoid,J-113863,CCR1,CCR3,CC chemokine receptor,Chemotaxis,collagen,arthritis,J 113863,J113863,CD18,anti-inflammatory
- 中文名:
- 1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE
- 中文别名:
- 化合物J-113863;1-(1-环辛烯-1-基甲基)-4-[[(2,7-二氯-9H-氧杂蒽-9-基)羰基]氨基]-1-乙基哌啶鎓碘化物
- CBNumber:
- CB72453425
- 分子式:
- C30H37Cl2IN2O2
- 分子量:
- 655.44
- MOL File:
- 353791-85-2.mol
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1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE化学性质
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储存条件:
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Store at +4°C
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溶解度:
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Soluble to 100 mM in DMSO and to 50 mM in ethanol
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形态:
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Powder
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颜色:
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Light yellow to yellow
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1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE性质、用途与生产工艺
J-113863 是一种有效的选择性的 CCR1 (CD18) 拮抗剂，对人和小鼠 CCR1 受体的 IC50 值分别为 0.9 nM 和 5.8 nM。J-113863 是人 CCR3 的强效拮抗剂 (IC50 为 0.58 nM)，还是小鼠 CCR3 的弱效拮抗剂 (IC50 为 460 nM)。J-113863 对 CCR2，CCR4 和 CCR5 以及 LTB4 或 TNF-α 受体没有活性。抗炎作用。
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CCR1
0.9 nM (IC
50
, Human CCR1)
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CCR1
5.8 nM (IC
50
, Mouse CCR1)
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CCR3
0.58 nM (IC
50
, Human CCR3)
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CCR3
460 nM (IC
50
, Mouse CCR3)
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Modified Vaccinia virus Ankara (MVA) but not MVA and vaccinia virus (VACV) infected MH-S cells increase the expression of the CXCR2 acting chemokine CXCL2. MH-S cells constitutively produce CCL2 and CCR1 acting chemokines CCL3, CCL5 and CCL9. Consequently, supernatants of mock treated and virus infected MH-S cells induce chemotaxis of murine promyelocyte MPRO cells and human monocytic THP-1 cells at the same level. However, supernatants of MVA infected MH-S cells significantly increase chemotaxis of the CCR2 deficient human monocytic cell line U-937. Chemotaxis of all above cell types is inhibited by J-113863.
J-113863 (3-10 mg/kg; intraperitoneal injection; once daily; for 11 days; DBA-1 male mice) treatment improves paw inflammation and joint damage, and dramatically decreases cell infiltration into joints in arthritic mice.
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Animal Model:
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DBA-1 male mice (10-12 weeks) induced with Collagen
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Dosage:
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3 mg/kg, 10 mg/kg
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Administration:
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Intraperitoneal injection; once daily; for 11 days
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Result:
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Improved paw inflammation and joint damage, and dramatically decreased cell infiltration into joints.
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1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-103360 | J-113863 | | 1 mg | 727元 |
| 2024/04/30 | HY-103360 | 1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE
J-113863 | 353791-85-2 | 5mg | 1600元 |
1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE
生产厂家
353791-85-2, 1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE 相关搜索:
- 1-(1-环辛烯-1-基甲基)-4-[[(2,7-二氯-9H-氧杂蒽-9-基)羰基]氨基]-1-乙基哌啶鎓碘化物
- 化合物J-113863
- 353791-85-2
- CCR,Inhibitor,inhibit,rheumatoid,J-113863,CCR1,CCR3,CC chemokine receptor,Chemotaxis,collagen,arthritis,J 113863,J113863,CD18,anti-inflammatory
- J 113863
- 1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE