MIVOTILATE
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- CAS号:
- 130112-42-4
- 英文名:
- Unii-0789652qul
- 英文别名:
- Ccris 8109;Mivotilate;Unii-0789652qul;Mivotilate [inn];YH439 >=98% (HPLC);Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl2-thiazol-2-yl)carbamoyl] acetate;Isopropyl 2-(1,3-dithietane-2-ylidine)-2-(N-(4-methyl-2-thiazol-2-yl)carbamoyl)acetate;2-(1,3-Dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-propanoic acid 1-methylethyl ester;Propanoic acid, 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-, 1-methylethyl ester
- 中文名:
- MIVOTILATE
- 中文别名:
- 化合物 T16082
- CBNumber:
- CB72496251
- 分子式:
- C12H14N2O3S3
- 分子量:
- 330.45
- MOL File:
- 130112-42-4.mol
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MIVOTILATE化学性质
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密度:
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1.467±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥5mg/mL
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形态:
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solid
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酸度系数(pKa):
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4.89±0.70(Predicted)
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颜色:
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Light yellow to yellow
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MIVOTILATE性质、用途与生产工艺
Mivotilate 是一种非毒性的,有效的芳烃受体 (aryl hydrocarbon receptor) 激动剂,具有护肝作用。
Aryl hydrocarbon receptor
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor. Mivotilate (YH439) has a novel activation mode that tolerates mutation of histidine 285 to tyrosine. Mivotilate induces cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor.
Mivotilate (YH439, 150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats, but shows no obvious effect on NADPH-dependent P450 oxidoreductase activity. Mivotilate (75-300 mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats.
MIVOTILATE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-100242 | MIVOTILATE Mivotilate | 130112-42-4 | 1mg | 1363元 |
2024/08/19 | HY-100242 | MIVOTILATE Mivotilate | 130112-42-4 | 5mg | 3000元 |
130112-42-4, MIVOTILATE 相关搜索:
- 化合物 T16082
- 130112-42-4
- YH439 >=98% (HPLC)
- Propanoic acid, 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-, 1-methylethyl ester
- Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl2-thiazol-2-yl)carbamoyl] acetate
- 2-(1,3-Dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-propanoic acid 1-methylethyl ester
- Unii-0789652qul
- Mivotilate [inn]
- Mivotilate
- Isopropyl 2-(1,3-dithietane-2-ylidine)-2-(N-(4-methyl-2-thiazol-2-yl)carbamoyl)acetate
- Ccris 8109