376638-65-2
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- CAS号:
- 376638-65-2
- 英文名:
- BVT-14225
- 英文别名:
- BVT-14225;BVT-14225, >98%;BVT14225;BVT 14225;inhibit,Inhibitor,BVT-14225,BVT14225;2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-n,n-diethylacetamide;4-Thiazoleacetamide,2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-;2-[2-(3-chloro-2-methylbenzenesulfonamido)-1,3-thiazol-4-yl]-N,N-diethylacetamide
- 中文名:
- 376638-65-2
- 中文别名:
- 化合物BVT14225;2-(2-(3-氯-2-甲苯磺酰胺基)噻唑-4-基)-N,N-二乙酰氨;2-(2-(3-氯-2-甲基苯磺酰胺)噻唑-4-基)-N,N-二乙基乙酰胺
- CBNumber:
- CB72662984
- 分子式:
- C16H20ClN3O3S2
- 分子量:
- 401.93
- MOL File:
- 376638-65-2.mol
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376638-65-2化学性质
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沸点:
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586.5±60.0 °C(Predicted)
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密度:
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1.373±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 27 mg/mL (67.18 mM)
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酸度系数(pKa):
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6.34±0.10(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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376638-65-2性质、用途与生产工艺
BVT-14225是选择性的11β羟基类固醇脱氢酶1型(11β-HSD1)抑制剂，IC50值为52 nM。
Selective inhibition of 11β-HSD1 decreases blood glucose concentrations in hyperglycaemic mice. Selective inhibitors of 11β-HSD1 have considerable potential as treatments for a number of diseases of great unmet medical need such as type 2 diabetes, obesity and metabolic syndrome, a multifactorial disorder. BVT-14225 shows high activity in the enzyme assay with 90% inhibition at 10 μM. It has an IC
50
for 11β-HSD1 on a human enzyme assay of 52 nM.
376638-65-2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-18055 | BVT-14225 | | 1 mg | 457元 |
| 2024/11/08 | HY-18055 | 376638-65-2
BVT-14225 | 376638-65-2 | 5mg | 1100元 |
376638-65-2, 376638-65-2 相关搜索:
- 抑制剂
- 2-(2-(3-氯-2-甲基苯磺酰胺)噻唑-4-基)-N,N-二乙基乙酰胺
- 化合物BVT14225
- 2-(2-(3-氯-2-甲苯磺酰胺基)噻唑-4-基)-N,N-二乙酰氨
- 376638-65-2
- 2-[2-(3-chloro-2-methylbenzenesulfonamido)-1,3-thiazol-4-yl]-N,N-diethylacetamide
- inhibit,Inhibitor,BVT-14225,BVT14225
- 2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-n,n-diethylacetamide
- BVT-14225, >98%
- BVT14225;BVT 14225
- 4-Thiazoleacetamide,2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-
- BVT-14225