118569-21-4
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- CAS号:
- 118569-21-4
- 英文名:
- Zileuton (sodiuM)
- 英文别名:
- Zileuton (sodiuM)
- 中文名:
- 118569-21-4
- 中文别名:
- 齐留通钠盐;化合物 T21836
- CBNumber:
- CB72677043
- 分子式:
- C11H13N2NaO2S
- 分子量:
- 260.29
- MOL File:
- 118569-21-4.mol
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118569-21-4化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Powder
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颜色:
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White to off-white
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118569-21-4性质、用途与生产工艺
Zileuton sodium (A 64077 sodium) 是一种有效的,选择性的 5-lipoxygenase 抑制剂,具有抗炎的作用。
In anti-CD3-treated cells, IL-2 decreases in Zileuton sodium (A 64077 sodium)-treated and untreated cells with increasing incubation time. Zileuton sodium (A 64077 sodium) likely reduces IL-2 levels by inhibiting 5-lipoxygenase, hence leukotriene B4 production, an IL-2 inducer.
In Zileuton sodium (A 64077 sodium) (5 mg/kg, p.o.) treated I/R rat, the effect of Zileuton to decrease NF-κB expression does not change significantly in the presence of COX inhibitors, and the group reveals significantly lower level of NF-κB staining. Zileuton (5 mg/kg, p.o.) treatment given to I/R rats decreases apoptotic index significantly. Zileuton has no significant effect on increased serum TNF-α levels in I/R group.
Zileuton sodium (A 64077 sodium) (1200 mg/kg) inhibits the polyp formation in APC
Δ468
colon and small intestine. Zileuton treatment inhibits the proliferation rates of non epithelial cells in polyps, and increases the apoptosis rates in polyps in rat. There is significant increase in the number of apoptotic cells in the Zileuton-treated cells both in small intestine and in the colon. The reduced proliferation rate may significantly contribute to the reduction of polyposis in both the small intestine and colon of Zileuton-fed APC
Δ468
mice.
118569-21-4
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-14164A | Zileuton sodium | | 1 mg | 127元 |
2024/08/19 | HY-14164A | Zileuton sodium | | 5 mg | 255元 |
118569-21-4, 118569-21-4 相关搜索:
- C11H11N2NaO2S
- 化合物 T21836
- 齐留通钠盐
- 118569-21-4
- Zileuton (sodiuM)