CZC25146
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- CAS号:
- 1191911-26-8
- 英文名:
- N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
- 英文别名:
- CZC-25146;CHEMBL2397014;CZC-25146 freebase;LRRK2 Inhibitor II;LRRK2 INHIBITOR II;CZC25146;CZC 25146;N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide;N-(2-((5-fluoro-2-((2-methoxy-4-
morpholinophenyl)amino)pyrimidin-
4-
yl)amino)phenyl)methanesulfonamide;N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide;CZC-25146/N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide;Methanesulfonamide, N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
- 中文名:
- CZC25146
- 中文别名:
- CZC-25146游离态;CZC 25146,LRRK2抑制剂;N-(2-((5-氟-2-((2-甲氧基-4-吗啉基苯基)氨基)嘧啶-4-基)氨基)苯基)甲磺酰胺
- CBNumber:
- CB72695999
- 分子式:
- C22H25FN6O4S
- 分子量:
- 488.54
- MOL File:
- 1191911-26-8.mol
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CZC25146化学性质
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沸点:
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697.4±65.0 °C(Predicted)
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密度:
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1.436±0.06 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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≥24.45 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
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形态:
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solid
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酸度系数(pKa):
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8.48±0.10(Predicted)
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颜色:
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Pale purple to purple
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CZC25146性质、用途与生产工艺
CZC-25146是一种有效、选择性的LRRK2抑制剂，对human wild type LRRK2和G2019S LRRK2的IC50分别为4.76 nM和6.87 nM。
| Target | Value |
human wild type LRRK2
(Cell-free assay)
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4.76 nM
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G2019S LRRK2
(Cell-free assay)
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6.87 nM
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用途
CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons鈥檚 disease, and is ATP-competitive.
CZC25146
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15800A | CZC25146
CZC-25146 | 1191911-26-8 | 5mg | 800元 |
| 2024/04/30 | HY-15800A | CZC25146
CZC-25146 | 1191911-26-8 | 10mM * 1mLin DMSO | 880元 |
1191911-26-8, CZC25146 相关搜索:
- API
- Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
- 药靶配体
- C22H25FN6O4S
- CZC 25146,LRRK2抑制剂
- N-(2-((5-氟-2-((2-甲氧基-4-吗啉基苯基)氨基)嘧啶-4-基)氨基)苯基)甲磺酰胺
- CZC-25146游离态
- 1191911-26-8
- Leucine-rich repeat kinase 2,Parkinson's disease,Inhibitor,LRRK2,CZC 25146,liver diseases,CZC25146,inhibit,neurons,CZC-25146,inflammatory,LRRK2 G2019S
- LRRK2 Inhibitor II
- LRRK2 INHIBITOR II;CZC25146;CZC 25146
- CHEMBL2397014
- Methanesulfonamide, N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
- CZC-25146/N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
- CZC-25146 freebase
- N-(2-((5-fluoro-2-((2-methoxy-4-
morpholinophenyl)amino)pyrimidin-
4-
yl)amino)phenyl)methanesulfonamide
- N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
- N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
- CZC-25146