网站主页 >> CAS数据库列表 >> 6-[1-(2-FLUOROPYRIDIN-3-YL)-5-METHYLTRIAZOL-4-YL]QUINOLINE
6-[1-(2-FLUOROPYRIDIN-3-YL)-5-METHYLTRIAZOL-4-YL]QUINOLINE
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- CAS号:
- 864863-72-9
- 英文名:
- FPTQ
- 英文别名:
- FPTQ;6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline;Quinoline, 6-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-
- 中文名:
- 6-[1-(2-FLUOROPYRIDIN-3-YL)-5-METHYLTRIAZOL-4-YL]QUINOLINE
- 中文别名:
- CBNumber:
- CB73137708
- 分子式:
- C17H12FN5
- 分子量:
- 305.31
- MOL File:
- 864863-72-9.mol
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6-[1-(2-FLUOROPYRIDIN-3-YL)-5-METHYLTRIAZOL-4-YL]QUINOLINE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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颜色:
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Light yellow to yellow
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6-[1-(2-FLUOROPYRIDIN-3-YL)-5-METHYLTRIAZOL-4-YL]QUINOLINE性质、用途与生产工艺
FPTQ 是一种有效的 mGluR1 拮抗剂,抑制人和鼠的 IC50 值分别为 6 nM 和 1.4 nM。FPTQ 具有抗氧化、抗炎作用。
Human mGluR1
6 nM (IC
50
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Mouse mGluR1
1.4 nM (IC
50
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FPTQ (0.5-10 μM) does not shows any cytotoxicity was not observed at 0.5, 1, 5, and 10 μM in RAW264.7 macrophage cells.FPTQ (1-20 μM; 24 hours) reduces LPS-induced NO production at > 1 μM FPTQ, and at 10 μM, FPTQ treatment causes a 31% anti-oxidant effect in RAW264.7 macrophage cells.FPTQ (1-20 μM; 24 hours) dramaticly decreases LPS-induced expression levels of IL-1β and Il-6. At a concentration of 10 μM, FPTQ causes a 27% and 44% reduction in the mRNA expression of IL-1β and Il-6, respectively in RAW264.7 macrophage cells.
RT-PCR
Cell Line:
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RAW264.7 macrophage cells
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Concentration:
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1, 10, or 20 μM
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Incubation Time:
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24 hours
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Result:
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Decreased IL-1β and IL-6 mRNA expression
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FPTQ (5-20 μM) decreases the number of neutrophils migrating to the amputation site in zebrafish larvae by tail amputation. In the tailfin wound method, the number of neutrophils collecting at the wound site also decreases in a dose-dependent manner in zebrafish.In a LPS-induced inflammation zebrafish model, LPS solution is injected into the yolks of Tg(mpx:EGFP)
i114
zebrafish larvae and exposed the zebrafish larvae immediately to FPTQ treatment.FPTQ (20 μM; 4 hours) significantly decreases the fluorescent neutrophils after yolk injection and has an anti-inflammatory effect during the early phase of inflammation.
6-[1-(2-FLUOROPYRIDIN-3-YL)-5-METHYLTRIAZOL-4-YL]QUINOLINE
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-100382 | 6-[1-(2-FLUOROPYRIDIN-3-YL)-5-METHYLTRIAZOL-4-YL]QUINOLINE FPTQ | 864863-72-9 | 5mg | 2300元 |
2024/04/30 | HY-100382 | 6-[1-(2-FLUOROPYRIDIN-3-YL)-5-METHYLTRIAZOL-4-YL]QUINOLINE FPTQ | 864863-72-9 | 10mM * 1mLin DMSO | 2530元 |
6-[1-(2-FLUOROPYRIDIN-3-YL)-5-METHYLTRIAZOL-4-YL]QUINOLINE
生产厂家
864863-72-9, 6-[1-(2-FLUOROPYRIDIN-3-YL)-5-METHYLTRIAZOL-4-YL]QUINOLINE 相关搜索:
- 864863-72-9
- Quinoline, 6-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-
- 6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline
- FPTQ