TB5
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- CAS号:
- 948841-07-4
- 英文名:
- TB5
- 英文别名:
- TB5;TB-5;TB 5;MAO,TB-5,Monoamine Oxidase,TB 5,TB5,Inhibitor,inhibit;1-(5-Bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-2-propene-1-one;2-Propen-1-one, 1-(5-bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-, (2E)-
- 中文名:
- TB5
- 中文别名:
- 化合物TB5
- CBNumber:
- CB73156590
- 分子式:
- C15H14BrNOS
- 分子量:
- 336.25
- MOL File:
- 948841-07-4.mol
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TB5化学性质
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沸点:
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468.5±45.0 °C(Predicted)
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密度:
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1.440±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 33 mg/ml; DMSO: 33 mg/ml; Ethanol: 1 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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4.30±0.24(Predicted)
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颜色:
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White to yellow
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TB5性质、用途与生产工艺
TB5是一种有效的、选择性MAO-B抑制剂，对MAO-B和MAO-A的Ki值分别为110 nM和1450 nM。
| Target | Value |
MAO-B
()
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110 nM(Ki)
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TB5 and TB8 interacts with the catalytic site of hMAO-B and hMAO-A with a competitive mode of inhibition. TB5 shows the best inhibitory activity and higher selectivity toward hMAO-B, with K
i
and SI values of 0.11±0.01μM and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A inhibition by compound TB8 are completely reversed after 24 h of dialysis. Cytotoxicity studies show TB5 is nontoxic at 5 and 25 μM, resulting in cell viabilities of 95.75% and 84.59 %, respectively.
Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1 μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8.
TB5
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100975 | TB5 | | 5 mg | 500元 |
| 2024/04/30 | HY-100975 | 948841-07-4
TB5 | 948841-07-4 | 10mM * 1mLin DMSO | 550元 |
948841-07-4, TB5 相关搜索:
- 药靶配体
- 化合物TB5
- 948841-07-4
- 2-Propen-1-one, 1-(5-bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-, (2E)-
- MAO,TB-5,Monoamine Oxidase,TB 5,TB5,Inhibitor,inhibit
- TB-5;TB 5
- 1-(5-Bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-2-propene-1-one
- TB5