214558-72-2
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- CAS号:
- 214558-72-2
- 英文名:
- YM-58790
- 英文别名:
- YM-58790;YM58790,YM 58790;YM-58790 hydrochloride
- 中文名:
- 214558-72-2
- 中文别名:
- 化合物 T13372
- CBNumber:
- CB73175605
- 分子式:
- C27H32ClN3O2
- 分子量:
- 466.02
- MOL File:
- 214558-72-2.mol
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214558-72-2化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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颜色:
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Light yellow to yellow
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214558-72-2性质、用途与生产工艺
YM-58790 是一种有效的 M3 muscarinic 受体拮抗剂,Ki 值为 15 nM。
Ki: 15 nM (M3 muscarinic receptor)
YM-58790 shows potent inhibitory effect on urinary bladder contraction, but has little effect on bradycardia. YM-58790 exhibits selective antagonism between urinary bladder contraction and salivary secretion in vitro.
YM-58790 (3 mg/kg, i.v.) does not inhibit oxotremorine-induced tremor in mice. The effect of YM-58790 on McN-A343-induced pressor in pithed rats, as an indication of M1 antagonism in vivo, is much less potent than bladder contraction. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to oxybutynin, and has appr ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats.
214558-72-2
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-101679 | YM-58790 | | 1 mg | 1772元 |
2024/08/19 | HY-101679 | YM-58790 | | 5 mg | 3900元 |
214558-72-2, 214558-72-2 相关搜索:
- 化合物 T13372
- 214558-72-2
- YM-58790 hydrochloride
- YM58790,YM 58790
- YM-58790