化合物 PANAMESINE
|
|
|
- CAS号:
- 139225-22-2
- 英文名:
- (5S)-5-[(4-benzo[1,3]dioxol-5-yl-4-hydroxy-1-piperidyl)methyl]-3-(4-methoxyphenyl)oxazolidin-2-one
- 英文别名:
- (5S)-5-[(4-benzo[1,3]dioxol-5-yl-4-hydroxy-1-piperidyl)methyl]-3-(4-methoxyphenyl)oxazolidin-2-one;2-Oxazolidinone, 5-[[4-(1,3-benzodioxol-5-yl)-4-hydroxy-1-piperidinyl]methyl]-3-(4-methoxyphenyl)-, (5S)-
- 中文名:
- 化合物 PANAMESINE
- 中文别名:
- 化合物 PANAMESINE
- CBNumber:
- CB73189590
- 分子式:
- C23H26N2O6
- 分子量:
- 426.46
- MOL File:
- 139225-22-2.mol
|
|
|
化合物 PANAMESINE化学性质
-
熔点:
-
165 °C(Solv: ethanol (64-17-5); dichloromethane (75-09-2))
-
|
-
沸点:
-
614.1±55.0 °C(Predicted)
-
|
-
密度:
-
1.343±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : 125 mg/mL (293.11 mM)
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
13.84±0.20(Predicted)
-
|
-
颜色:
-
Off-white to light yellow
-
|
化合物 PANAMESINE性质、用途与生产工艺
Panamesine (EMD 57445) 是一种高亲和力的 sigma 受体配体，IC50 为 6 nM，有潜力用于非典型抗精神病的研究。
IC50: 6 nM (sigma receptor)
Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex.
|
Animal Model:
|
Female Sprague Dawley rats aged 2 months with a body weights of 200-250 g
|
|
Dosage:
|
0.3, 1, 3, 30 mg/kg
|
|
Administration:
|
Subcutanous injections
|
|
Result:
|
Specific c-fos gene expression was detected at all concentrations (0.3 mg/kg, 1 mg/kg, 3 mg/kg, 30 mg/kg) tested in frontal, parietal, perirhinal, temporal, piriform, insular, limbic, cingulate and occipital cortex.
|
化合物 PANAMESINE
上下游产品信息
上游原料
下游产品
139225-22-2, 化合物 PANAMESINE 相关搜索:
- 抑制剂
- 化合物 PANAMESINE
- 139225-22-2
- 2-Oxazolidinone, 5-[[4-(1,3-benzodioxol-5-yl)-4-hydroxy-1-piperidinyl]methyl]-3-(4-methoxyphenyl)-, (5S)-
- (5S)-5-[(4-benzo[1,3]dioxol-5-yl-4-hydroxy-1-piperidyl)methyl]-3-(4-methoxyphenyl)oxazolidin-2-one