CPPG
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- CAS号:
- 183364-82-1
- 英文名:
- CPPG
- 英文别名:
- CPPG;rac-CPPG;(RS)-CPPG;(RS)-α-Cyclopropyl-4-phosphonophenylglycine;(RS)-ALPHA-CYCLOPROPYL-4-PHOSPHONOPHENYLGLYCINE;(+/-)-ALPHA-CYCLOPROPYL-4-PHOSPHONOPHENYLGLYCINE;Benzeneacetic acid, α-amino-α-cyclopropyl-4-phosphono-;2-Amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid;CPPG, group II/III metabotropic glutamate receptor antagonist
- 中文名:
- CPPG
- 中文别名:
- 化合物 T10880;CPPG,GROUP II/III METABOTROPIC GLUTAMATE RECEPTOR拮抗剂
- CBNumber:
- CB7356331
- 分子式:
- C11H14NO5P
- 分子量:
- 271.21
- MOL File:
- 183364-82-1.mol
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CPPG化学性质
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储存条件:
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Store at RT
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溶解度:
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H2O: >5mg/mL
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形态:
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Solid
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颜色:
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white to beige
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CPPG性质、用途与生产工艺
CPPG ((RS)-CPPG) 是一种有效的 II/III 型 mGlu 受体拮抗剂。CPPG 对大鼠大脑皮层中的 III 组 (IC50=2.2 nM) 比对 II 组（(IC50=46.2 nM) mGlu 受体有一定的选择性 (约 20 倍)。CPPG 对 I 组 mGlu 受体的作用较弱。
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group III mGlu receptors
2.2 nM (IC
50
)
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group II mGlu receptors
46.2 nM (IC
50
)
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CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC
50
=2.2 nM)- and L-CCG-I (IC
50
=46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells.
CPPG
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-101333 | CPPG | | 1 mg | 990元 |
| 2024/11/08 | HY-101333 | CPPG | | 5 mg | 2610元 |
CPPG
生产厂家
全球有 55家供应商
CPPG国内生产厂家
183364-82-1, CPPG 相关搜索:
- Glutamate receptor
- C11H14NO5P
- CPPG,GROUP II/III METABOTROPIC GLUTAMATE RECEPTOR拮抗剂
- 化合物 T10880
- 183364-82-1
- CPPG, group II/III metabotropic glutamate receptor antagonist
- 2-Amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid
- rac-CPPG
- Benzeneacetic acid, α-amino-α-cyclopropyl-4-phosphono-
- (RS)-α-Cyclopropyl-4-phosphonophenylglycine
- (RS)-CPPG
- (RS)-ALPHA-CYCLOPROPYL-4-PHOSPHONOPHENYLGLYCINE
- (+/-)-ALPHA-CYCLOPROPYL-4-PHOSPHONOPHENYLGLYCINE
- CPPG