AZ82
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- CAS号:
- 1449578-65-7
- 英文名:
- AZ82
- 英文别名:
- AZ82;AZ82,AZ-82;KIFC1 inhibitor AZ82;KIFC1 Inhibitor, AZ82 - CAS 1449578-65-7 - Calbiochem;3-Pyridinepropanamide, α-[[(5-methyl-4-propyl-2-thienyl)carbonyl]amino]-N-(3R)-3-pyrrolidinyl-6-[3-(trifluoromethoxy)phenyl]-, (αR)-;5-methyl-N-[(2R)-1-oxo-1-[[(3R)-pyrrolidin-3-yl]amino]-3-[6-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]propan-2-yl]-4-propylthiophene-2-carboxamide
- 中文名:
- AZ82
- 中文别名:
- 化合物 T10428
- CBNumber:
- CB73595708
- 分子式:
- C28H31F3N4O3S
- 分子量:
- 560.63
- MOL File:
- 1449578-65-7.mol
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AZ82化学性质
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沸点:
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707.9±60.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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+2C to +8C
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溶解度:
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DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
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形态:
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Yellow film
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酸度系数(pKa):
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13.25±0.46(Predicted)
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颜色:
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White to off-white
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AZ82性质、用途与生产工艺
AZ82 是一种驱动蛋白样蛋白 KIFC1 (HSET/KIFC1) 的选择性抑制剂，其 Ki 值和 IC50 值分别为 43 nM 和 300 nM。
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HSET/KIFC1
300 nM (IC
50
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HSET/KIFC1
43 nM (Ki)
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AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes with an IC
50
of 0.90 ± 0.09 μM for mant-ATP binding and 1.26 ± 0.51 μM for mant-ADP releasing.
AZ82
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-12241 | AZ82 | | 1 mg | 920元 |
| 2024/08/19 | HY-12241 | AZ82
AZ82 | 1449578-65-7 | 5mg | 2200元 |
1449578-65-7, AZ82 相关搜索:
- C28H31F3N4O3S
- 化合物 T10428
- 1449578-65-7
- AZ82,AZ-82
- 3-Pyridinepropanamide, α-[[(5-methyl-4-propyl-2-thienyl)carbonyl]amino]-N-(3R)-3-pyrrolidinyl-6-[3-(trifluoromethoxy)phenyl]-, (αR)-
- KIFC1 inhibitor AZ82
- KIFC1 Inhibitor, AZ82 - CAS 1449578-65-7 - Calbiochem
- AZ82
- 5-methyl-N-[(2R)-1-oxo-1-[[(3R)-pyrrolidin-3-yl]amino]-3-[6-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]propan-2-yl]-4-propylthiophene-2-carboxamide