CPD1599
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- CAS号:
- 1883650-96-1
- 英文名:
- CDDO-3-P-Im
- 英文别名:
- CPD1599;CPDB1599;CDDO-3-P-Im;CDDO-2P-Imidazolide;Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(2-pyridinyl)-1H-imidazol-1-yl]-
- 中文名:
- CPD1599
- 中文别名:
- 化合物 T13602;化合物CDDO-2P-IM
- CBNumber:
- CB73956895
- 分子式:
- C39H46N4O3
- 分子量:
- 618.81
- MOL File:
- 1883650-96-1.mol
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CPD1599化学性质
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沸点:
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766.1±70.0 °C(Predicted)
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密度:
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1.25±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (404.00 mM)
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酸度系数(pKa):
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1.60±0.19(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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CPD1599性质、用途与生产工艺
CDDO-2P-Im 是 CDDO 咪唑胺类似物，具有化学预防作用。CDDO-2P-Im 可降低小鼠肺癌模型肺肿瘤的大小和严重程度。
CDDO-2P-Im (100 nM; 4 days) induces differentiation of U937 cells at 100 nM.
CDDO-2P-Im suppresses NO production in RAW264.7 cells with an IC
50
of 5.8 nM.
Apoptosis Analysis
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Cell Line:
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U937 cells
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Concentration:
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30 nM, 100 nM
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Incubation Time:
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4 days
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Result:
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Induced differentiation of U937 cells at 100 nM.
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CDDO-2P-Im is more stable than CDDO-Im in pharmacokinetic studies.
CDDO-2P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.
CDDO-2P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.
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Animal Model:
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Seven week-old female A/J mice
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Dosage:
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50 mg/kg, 200 mg/kg
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Administration:
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Diet; for 16 weeks
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Result:
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Decreased the number, the size and the severity of tumors.
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CPD1599
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-135953 | CDDO-3P-Im | | 1 mg | 952元 |
| 2024/04/30 | HY-135953 | CPD1599
CDDO-3P-Im | 1883650-96-1 | 5mg | 2500元 |
1883650-96-1, CPD1599 相关搜索:
- 抑制剂
- 化合物CDDO-2P-IM
- 化合物 T13602
- 1883650-96-1
- Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(2-pyridinyl)-1H-imidazol-1-yl]-
- CDDO-2P-Imidazolide
- CPDB1599
- CPD1599
- CDDO-3-P-Im