H-ISQAVHAAHAEINEAGR-OH
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- CAS号:
- 英文名:
- CHICKEN OVALBUMIN FRAGMENT (323-339)
- 英文别名:
- OVA PEPTIDE (323-339);H-ISQAVHAAHAEINEAGR-OH;CHICKEN OVALBUMIN FRAGMENT (323-339);H-ILE-SER-GLN-ALA-VAL-HIS-ALA-ALA-HIS-ALA-GLU-ILE-ASN-GLU-ALA-ALA-GLY-ARG-OH
- 中文名:
- H-ISQAVHAAHAEINEAGR-OH
- 中文别名:
- CBNumber:
- CB7404856
- 分子式:
- C77H125N27O26
- 分子量:
- 1844.98
- MOL File:
- Mol file
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H-ISQAVHAAHAEINEAGR-OH化学性质
H-ISQAVHAAHAEINEAGR-OH性质、用途与生产工艺
OVA Peptide (323-339) 代表卵清蛋白(OVA)的T和B细胞表位,这对于BALB/c小鼠的瞬时超敏反应的产生和发展是重要的。
When pulsed with 0.01 μM of OVA Peptide (323-339), M2-expressing B cells lead to an increase in the number of T
H
cells mobilizing calcium, compared to M2Y-expressing B cells. To assess if M2-expressing B cells are also able to promote stronger individual responses, we quantified the 405/530 ratio MFI of responding T
H
cells.
OVA Peptide (323-339) represents a T and B cell epitope of OVA, which is important in the generation and development of immediate hypersensitivity responses in BALB/c mice. Daily aerosolization of OVA Peptide (323-339) for 20 minutes over a period of 10 days has been as effective in the stimulation of a serum anti-OVA IgE antibody response as sensitization to native OVA by the same route. After sensitization to native OVA, the majority of the IgE anti-OVA response is directed against OVA Peptide (323-339). Evaluated by hematoxylin/eosin and major basic protein immunohistochemical stainings, OVA and OVA Peptide (323-339) induce similar lung inflammation. Interestingly, significant serum total IgE and OVA-specific IgE are observed in OVA mice when compared to saline control. OVA Peptide (323-339) mice show higher serum OVA-specific IgE, OVA Peptide (323-339)-specific IgE, IL-4 and lower IFN-γ similar to OVA mice. The proliferative response to OVA is found in cultured splenocytes of both OVA and OVA Peptide (323-339) mice, while the similar proliferative response to OVA Peptide (323-339) is only observed in the splenocytes of OVA Peptide (323-339)-sensitized and challenged mice. Although OVA Peptide (323-339) induces a Th2-like response in the mouse model as does OVA, OVA Peptide (323-339) has clearly limited immunogenic potency to activate OVA-sensitized and challenged mice splenocytes, unlike OVA.
H-ISQAVHAAHAEINEAGR-OH
上下游产品信息
上游原料
下游产品
H-ISQAVHAAHAEINEAGR-OH 试剂级价格
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-P0286 | H-ISQAVHAAHAEINEAGR-OH OVA Peptide 323-339 | | 1 mg | 1100元 |
2024/08/19 | HY-P0286 | H-ISQAVHAAHAEINEAGR-OH OVA Peptide 323-339 | | 5mg | 4400元 |
H-ISQAVHAAHAEINEAGR-OH
生产厂家
H-ISQAVHAAHAEINEAGR-OH 相关搜索:
- H-ISQAVHAAHAEINEAGR-OH
- OVA PEPTIDE (323-339)
- CHICKEN OVALBUMIN FRAGMENT (323-339)
- H-ILE-SER-GLN-ALA-VAL-HIS-ALA-ALA-HIS-ALA-GLU-ILE-ASN-GLU-ALA-ALA-GLY-ARG-OH