AGN192836
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- CAS号:
- 171102-29-7
- 英文名:
- AGN192836
- 英文别名:
- AGN192836;1H-Imidazol-2-amine, N-(2,3-dihydro-5-methyl-1,4-benzodioxin-6-yl)-;N-(5-Methyl-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-imidazol-2-amine
- 中文名:
- AGN192836
- 中文别名:
- 化合物 T10264;化合物 AGN 192836;N-(5-甲基-2,3-二氢苯并[B][1,4]DIOXIN-6-基)-1H-咪唑-2-胺
- CBNumber:
- CB74667505
- 分子式:
- C12H13N3O2
- 分子量:
- 231.25
- MOL File:
- 171102-29-7.mol
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AGN192836化学性质
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沸点:
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411.2±55.0 °C(Predicted)
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密度:
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1.342±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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14.29±0.10(Predicted)
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颜色:
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Off-white to pale purple
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AGN192836性质、用途与生产工艺
AGN 192836是有效，选择性的肾上腺素受体 (α2 adrenergic) 激动剂，对α2A，α2B 和 α2C的 EC50 值分别为8.7，41和6.6 nM。
EC50: 8.7 nM (α2A), 41 nM (α2B), 6.6 nM (α2C)
Ki: 1.7 nM (α2A), 82 nM (α2B), 19 nM (α2C)
Binding assays demonstrates that AGN 192836 is 1200-fold selective for the α2A-receptor relative to the α1-receptor, 50-fold selective for the α2A-receptor relative to the α2B-receptor, and 10-fold selective for the α2Areceptor relative to the α2C-receptor.
AGN 192836 is equally efficacious when compared to brimonidine for the reduction of intraocular pressure upon topical administration to the rabbit and more efficacious than brimonidine for the reduction of blood pressure upon intravenous administration to monkey.
AGN192836
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-100300 | AGN192836
AGN 192836 | | 1 mg | 1590元 |
| 2024/11/08 | HY-100300 | AGN 192836 | | 5 mg | 3500元 |
171102-29-7, AGN192836 相关搜索:
- 抑制剂
- 化合物 AGN 192836
- N-(5-甲基-2,3-二氢苯并[B][1,4]DIOXIN-6-基)-1H-咪唑-2-胺
- 化合物 T10264
- 171102-29-7
- N-(5-Methyl-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-imidazol-2-amine
- 1H-Imidazol-2-amine, N-(2,3-dihydro-5-methyl-1,4-benzodioxin-6-yl)-
- AGN192836