TRPM8 拮抗剂
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- CAS号:
- 259674-19-6
- 英文名:
- TRPM8 Antagonist
- 英文别名:
- TRPM8 Antagonist;TRPM8 antagonist 2;TRPM8 ANTAGONIST;259674-19-6;Methyl N,N-dibenzyl-L-tryptophanate;Methyl Na,Na-dibenzyl-L-tryptophanate;L-Tryptophan, N,N-bis(phenylmethyl)-, methyl ester;TRPM8 antagonist 2,inhibit,Transient receptor potential channels,TRP Channel,Inhibitor,TRPM-8 antagonist 2
- 中文名:
- TRPM8 拮抗剂
- 中文别名:
- 化合物TRPM8 ANTAGONIST 2;TRPM8 ANTAGONIST 2 游离;(S)-2-(二苄氨基)-3-(1H-吲哚-3-基)丙酸甲酯
- CBNumber:
- CB74718445
- 分子式:
- C26H26N2O2
- 分子量:
- 398.5
- MOL File:
- 259674-19-6.mol
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TRPM8 拮抗剂化学性质
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沸点:
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567.5±50.0 °C(Predicted)
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密度:
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1.195±0.06 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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DMSO : 160 mg/mL (401.51 mM)
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酸度系数(pKa):
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17.02±0.30(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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TRPM8 拮抗剂性质、用途与生产工艺
TRPM8 antagonist 2 (TRPM8 Antagonist)是一种有效的 TRPM8 的拮抗剂，IC50值为0.2 nM，可用于神经性疼痛综合征的药理治疗。
| Target | Value |
TRPM8
(Cell-free assay)
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0.2 nM
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TRPM8 antagonist 2 (Compound 14) is a potent and selective TRPM8 antagonist, with an IC
50
of 0.2 nM, used in the research of neuropathic pain syndromes. TRPM8 antagonist 2 potently inhibits menthol-induced increase in intracellular Ca
2+
levels in Ca
2+
fluorimetric assays in HEK293 cells stably expressing the rat isoform of TRPM8 channels (IC
50
, 40 nM).
TRPM8 antagonist 2 (1, 10, and 30 mg/kg, s.c.) shows a marked, dose-dependent antinociceptive activity, and inhibits wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at 30 mg/kg. In addition, TRPM8 antagonist 2 (0.1 and 1 μg, s.c.) attenuates Oxaliplatin (OXP)-induced cold allodynia in mice.
TRPM8 拮抗剂
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-112430 | 259674-19-6
TRPM8 antagonist 2 | 259674-19-6 | 5mg | 900元 |
| 2024/08/19 | HY-112430 | 259674-19-6
TRPM8 antagonist 2 | 259674-19-6 | 10mM * 1mLin DMSO | 990元 |
259674-19-6, TRPM8 拮抗剂 相关搜索:
- API
- 抑制剂
- 药靶配体
- TRPM8 ANTAGONIST 2 游离
- (S)-2-(二苄氨基)-3-(1H-吲哚-3-基)丙酸甲酯
- 化合物TRPM8 ANTAGONIST 2
- 259674-19-6
- TRPM8 antagonist 2,inhibit,Transient receptor potential channels,TRP Channel,Inhibitor,TRPM-8 antagonist 2
- Methyl Na,Na-dibenzyl-L-tryptophanate
- Methyl N,N-dibenzyl-L-tryptophanate
- L-Tryptophan, N,N-bis(phenylmethyl)-, methyl ester
- TRPM8 antagonist 2
- TRPM8 ANTAGONIST;259674-19-6
- TRPM8 Antagonist