Isocoptisine acetate
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- CAS号:
- 30426-66-5
- 英文名:
- Isocoptisine acetate
- 英文别名:
- Isocoptisine acetate;Pseudocoptisine acetate
- 中文名:
- Isocoptisine acetate
- 中文别名:
- 异黄连碱(乙酸盐);化合物 T12570
- CBNumber:
- CB74806614
- 分子式:
- C21H17NO6
- 分子量:
- 379.37
- MOL File:
- 30426-66-5.mol
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Isocoptisine acetate化学性质
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熔点:
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146-147 °C
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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Isocoptisine acetate性质、用途与生产工艺
Pseudocoptisine (Isocoptisine) acetate 是从延胡索中分离得到的具有苄基异喹啉骨架的四元生物碱。Pseudocoptisine acetate 抑制乙酰胆碱酯酶 (AChE) 活性,IC50 为12.8μM。具有抗炎和抗遗忘作用。
Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells.
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions.
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells.
The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test.
Isocoptisine acetate
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2023/03/20 | HY-N6894 | Isocoptisine acetate Pseudocoptisine acetate | 30426-66-5 | 1mg | 7240元 |
2023/03/20 | HY-N6894 | Isocoptisine acetate Pseudocoptisine acetate | 30426-66-5 | 5mg | 21710元 |
Isocoptisine acetate
生产厂家
30426-66-5, Isocoptisine acetate 相关搜索:
- 标准品
- 化合物 T12570
- 异黄连碱(乙酸盐)
- 30426-66-5
- Pseudocoptisine acetate
- Isocoptisine acetate