RTI-13951-33 hydrochloride
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- CAS号:
- 英文名:
- RTI-13951-33 hydrochloride
- 英文别名:
- RTI-13951-33 hydrochloride
- 中文名:
- RTI-13951-33 hydrochloride
- 中文别名:
- 化合物 T12778;化合物 RTI-13951-33 HYDROCHLORIDE
- CBNumber:
- CB75419839
- 分子式:
- C??H??Cl?N?O?
- 分子量:
- 0
- MOL File:
- Mol file
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RTI-13951-33 hydrochloride化学性质
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形态:
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Solid
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颜色:
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White to light yellow
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RTI-13951-33 hydrochloride性质、用途与生产工艺
RTI-13951-33 hydrochloride 是一种有效、选择性、可透过血脑屏障的 GPR88 激动剂,在 GPR88 cAMP 功能性实验中,EC50 值为 25 nM。RTI-13951-33 hydrochloride 可以减少大鼠酒精强化和摄取行为。
RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC
50
of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 elevates [
35
S]-GTPγS binding (EC
50
, 535 nM) in mouse striatal membranes but not in membranes from GPR88 KO mice.
RTI-13951-33 has weak affinities at kappa opioid receptor (KOR; K
i
, 2.29 μM), vesicular monoamine transporter (VMAT; K
i
, 4.23 μM), and moderate affinity at serotonin transporter (SERT; K
i
, 0.75 μM), however, RTI-13951-33 poorly inhibits SERT (IC
50
, 25.1±2.7 μM).
RTI-13951-33 (10 and 20 mg/kg, i.p.) dose-dependently decreases alcohol lever responses in a rat model of alcohol self-administration.
RTI-13951-33 (10 mg/kg, i.p.) has sufficient brain penetration, with t
1/2
of 48 min and 87 min in rat plasma and brain.
RTI-13951-33 hydrochloride
上下游产品信息
上游原料
下游产品
RTI-13951-33 hydrochloride 试剂级价格
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-112612A | RTI-13951-33 hydrochloride | | 1 mg | 1750元 |
2024/08/19 | HY-112612A | RTI-13951-33 hydrochloride RTI-13951-33 hydrochloride | | 5mg | 4400元 |
RTI-13951-33 hydrochloride
生产厂家
RTI-13951-33 hydrochloride 相关搜索:
- 抑制剂
- 化合物 RTI-13951-33 HYDROCHLORIDE
- 化合物 T12778
- RTI-13951-33 hydrochloride