Seladelpar sodium salt
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- CAS号:
- 英文名:
- Seladelpar sodium salt
- 英文别名:
- Seladelpar sodium salt
- 中文名:
- Seladelpar sodium salt
- 中文别名:
- 化合物 T12876
- CBNumber:
- CB75419844
- 分子式:
- C??H??F?NaO?S
- 分子量:
- 0
- MOL File:
- Mol file
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Seladelpar sodium salt化学性质
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形态:
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Solid
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颜色:
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White to off-white
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Seladelpar sodium salt性质、用途与生产工艺
Seladelpar sodium salt (MBX-8025) 是一种具有口服活性的、选择性的 PPARδ 激动剂,EC50 值为 2 nM。它对 PPARδ 的选择性分别是对 PPARα 和 PPARγ 的 750 和 2500 多倍。
MBX-8025 is an orally active, potent (EC
50
=2 nM), and specific (750-fold and 2500-fold compared with PPARα or PPARγ receptors, respectively) PPARδ agonist being developed as a lipid-altering agent.
In atherogenic diet-fed
Wt
mice, administration of Seladelpar sodium salt reduces body weight by ~18% (P<0.05). In contrast, Seladelpar sodium salt produces minimal effect on body weight in atherogenic diet-fed
foz/foz
mice. Seladelpar sodium salt lowers serum alanine aminotransferase (ALT) levels in
foz/foz
mice (P<0.05) and similarly (but not significantly) in
Wt
mice. Seladelpar sodium salt normalizes serum cholesterol and decreases triglycerides in both genotypes (P<0.05). Seladelpar sodium salt abolishes hepatocyte ballooning (P<0.05) and decreases the nonalcoholic fatty liver disease (NAFLD) activity score by ~50%. Seladelpar sodium salt also significantly reduces sirius red-positive areas in
foz/foz
mice (P<0.05).
Seladelpar sodium salt
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下游产品
Seladelpar sodium salt 试剂级价格
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-19522A | Seladelpar sodium salt | | 1 mg | 409元 |
2024/04/30 | HY-19522A | Seladelpar sodium salt Seladelpar sodium salt | | 5mg | 900元 |
Seladelpar sodium salt
生产厂家
Seladelpar sodium salt 相关搜索:
- CHFNaOS
- 化合物 T12876
- Seladelpar sodium salt