Apamin (TFA)
|
|
|
- CAS号:
- 英文名:
- Apamin (TFA)
- 英文别名:
- Apamin (TFA)
- 中文名:
- Apamin (TFA)
- 中文别名:
- CBNumber:
- CB75848756
- 分子式:
- 分子量:
- 0
- MOL File:
- Mol file
|
|
|
Apamin (TFA)化学性质
-
形态:
-
Solid
-
|
-
颜色:
-
White to off-white
-
|
Apamin (TFA)性质、用途与生产工艺
Apamin TFA (Apamine TFA) 是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素，是一种 Ca2+ 激活的 K+ (SK) 通道的特异性和选择性的阻断剂，具有抗炎和抗纤维化的作用。
Apamin (0.5-2 µg/mL; 24 hours; HSC-T6 cells) treatment markedly reduces the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Apamin treatment abrogats the activation of p-Smad2/3 and Smad4 induced by TGF-β1.
Western Blot Analysis
|
Cell Line:
|
HSC-T6 cells
|
|
Concentration:
|
0.5 µg/mL, 1 µg/mL and 2 µg/mL
|
|
Incubation Time:
|
24 hours
|
|
Result:
|
Markedly reduced the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Abrogated the activation of p-Smad2/3 and Smad4 induced by TGF-β1.
|
Apamin (0.1 mg/kg; intraperitoneal injection; twice a week; for 4 weeks; C57BL/6 male mice) treatment results in decreased liver injury and proinflammatory cytokine levels. Apamin suppresses the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice.
|
Animal Model:
|
8-week-old C57BL/6 male mice (20-25 g) with DDC feeding
|
|
Dosage:
|
0.1 mg/kg
|
|
Administration:
|
Intraperitoneal injection; twice a week; for 4 weeks
|
|
Result:
|
Resulted in decreased liver injury and proinflammatory cytokine levels. Suppressed the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the DDC-fed mice.
|
Apamin (TFA)
上下游产品信息
上游原料
下游产品
Apamin (TFA) 试剂级价格
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-P0256A | Apamin (TFA)
Apamin TFA | | 500μg | 1500元 |
| 2024/08/19 | HY-P0256A | Apamin (TFA)
Apamin TFA | | 1mg | 2500元 |