CB1151
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- CAS号:
- 182369-28-4
- 英文名:
- CB1151
- 英文别名:
- CB1151;1,3-Cyclohexanediol, 5-[(2E)-[(1S,3aS,7aS)-1-[(1R)-1-[(3-ethyl-3-hydroxypentyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)- (9CI)
- 中文名:
- CB1151
- 中文别名:
- 化合物 T10695
- CBNumber:
- CB75848817
- 分子式:
- C28H46O4
- 分子量:
- 446.66
- MOL File:
- 182369-28-4.mol
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CB1151化学性质
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沸点:
-
601.5±55.0 °C(Predicted)
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密度:
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1.07±0.1 g/cm3(Predicted)
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储存条件:
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4°C, protect from light, stored under nitrogen
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
-
14.43±0.40(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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CB1151性质、用途与生产工艺
CB1151 是 1,25 二羟基维生素D3 (VD) 的 20 表位类似物 ( 20-epi analogue of VD),具有有效的抗肿瘤作用。CB1151 抑制 MCF-7 细胞生长, IC50 值为 0.82 nM。
CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [
3
H]-thymidine incorporation, exhibits an IC
50
value of 0.82 nM.
CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC
50
of 1.2 nM, the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC
50
=3.2nM) in MCF-7 cells transfected with the CAT reporter.
CB1151 shows a functional dissociation constant (K
df
) value of 3.6 nM. The ligand concentration that provides 50% of protease-resistant VDR fragment is defined by K
df
, this is different from that of the traditional dissociation constant (K
d
).
Cell Proliferation Assay
Cell Line:
|
MCF-7 cell
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Concentration:
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0 nM; 0.1nM; 0.5nM; 0.8nM; 1nM; 5nM; 10 nM
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Incubation Time:
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5 days
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Result:
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Inhibits MCF-7 cells growth.
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CB1151
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/01/25 | HY-100219 | CB1151 CB1151 | 182369-28-4 | 1mg | 5000元 |
182369-28-4, CB1151 相关搜索:
- 化合物 T10695
- 182369-28-4
- 1,3-Cyclohexanediol, 5-[(2E)-[(1S,3aS,7aS)-1-[(1R)-1-[(3-ethyl-3-hydroxypentyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)- (9CI)
- CB1151