六-D-精氨酸 TFA
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- CAS号:
- 958204-56-3
- 英文名:
- Furin Inhibitor II TFA
- 英文别名:
- H-Arg6-NH2;Hexa-D-arginine TFA;Furin Inhibitor II TFA;(R)-2-amino-5-((diaminomethylene)amino)-N-((6R,9R,12R,15R,18R)-1,1,23,23-tetraamino-6-carbamoyl-9,12,15-tris(3-((diaminomethylene)amino)propyl)-8,11,14,17-tetraoxo-2,7,10,13,16,22-hexaazatricosa-1,22-dien-18-yl)pentanamide 2,2,2-trifluoroacetate
- 中文名:
- 六-D-精氨酸 TFA
- 中文别名:
- 六-D-精氨酸 TFA
- CBNumber:
- CB78054875
- 分子式:
- C38H76F3N25O8
- 分子量:
- 1068.19
- MOL File:
- 958204-56-3.mol
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六-D-精氨酸 TFA性质、用途与生产工艺
Hexa-D-arginine TFA (Furin Inhibitor II TFA) 是一种稳定的 furin 抑制剂，对 furin，PACE4 和 PC1 的 Ki 值分别为 106 nM，580 nM 和 13.2 μM。Hexa-D-arginine TFA 在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。
Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)
Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.
Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.
六-D-精氨酸 TFA
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958204-56-3, 六-D-精氨酸 TFA 相关搜索:
- 六-D-精氨酸 TFA
- 958204-56-3
- (R)-2-amino-5-((diaminomethylene)amino)-N-((6R,9R,12R,15R,18R)-1,1,23,23-tetraamino-6-carbamoyl-9,12,15-tris(3-((diaminomethylene)amino)propyl)-8,11,14,17-tetraoxo-2,7,10,13,16,22-hexaazatricosa-1,22-dien-18-yl)pentanamide 2,2,2-trifluoroacetate
- H-Arg6-NH2
- Hexa-D-arginine TFA
- Furin Inhibitor II TFA