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(E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮
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- CAS号:
- 2041072-41-5
- 英文名:
- 4(3H)-Quinazolinone, 2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-(2-methoxyphenyl)-
- 英文别名:
- ICCB280;4(3H)-Quinazolinone, 2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-(2-methoxyphenyl)-;ICCB 280,Inhibitor,ICCB280,Apoptosis,differentiation,proliferation,C/EBPα,anti-leukemic,ICCB-280,inhibit
- 中文名:
- (E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮
- 中文别名:
- 化合物ICCB280;(E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮
- CBNumber:
- CB78135633
- 分子式:
- C23H18N2O4
- 分子量:
- 386.4
- MOL File:
- 2041072-41-5.mol
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(E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮化学性质
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沸点:
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624.1±65.0 °C(Predicted)
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密度:
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1.28±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 83.33 mg/mL (215.66 mM)
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形态:
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Solid
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酸度系数(pKa):
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9.40±0.10(Predicted)
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颜色:
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Light yellow to yellow
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(E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮性质、用途与生产工艺
ICCB280 是一种有效的 C/EBPα 诱导剂。ICCB280 通过激活 C/EBPα 并影响其下游靶点 (例如 C/EBPε ,G-CSFR 和 c-Myc),具有抗白血病特性,包括终末分化,增殖停滞和凋亡。
ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC
50
of 8.6 μM.
ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells.
ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells.
Cell Viability Assay
Cell Line:
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HL-60 cells
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Concentration:
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0.1, 0.5, 1, 5, 10, 50 μM
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Incubation Time:
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48 hours
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Result:
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Induced cell growth arrest, with an IC
50
of 8.6 μM.
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Western Blot Analysis
Cell Line:
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HL-60 cells
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Concentration:
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10 μM
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Incubation Time:
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2, 4, 6, 8 days
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Result:
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Upregulated the C/EBPα protein on day 4.
Increased the C/EBPε expression on day 6.
No changes in C/EBPβ expression through the 8 days of the experiment.
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(E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-134333 | (E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮 ICCB280 | 2041072-41-5 | 5mg | 2200元 |
2024/08/19 | HY-134333 | (E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮 ICCB280 | 2041072-41-5 | 10 mM * 1 mLin DMSO | 2400元 |
(E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮
生产厂家
2041072-41-5, (E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮 相关搜索:
- 抑制剂
- 药靶配体
- 化合物ICCB280
- (E)-2-(3,4-二羟基苯乙烯基)-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮
- 2041072-41-5
- ICCB 280,Inhibitor,ICCB280,Apoptosis,differentiation,proliferation,C/EBPα,anti-leukemic,ICCB-280,inhibit
- ICCB280
- 4(3H)-Quinazolinone, 2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-(2-methoxyphenyl)-