化合物 T10607
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- CAS号:
- 2446154-91-0
- 英文名:
- [1,?1'-?Biphenyl]?-?4-?carboxamide, N-?[(3R,?6R,?7R)?-?3,?4,?5,?6,?7,?8,?9,?10-?octahydro-?7-?methoxy-?3,?6,?9-?trimethyl-?10-?oxo-?2H-?1,?4,?9-?benzoxadiazacyclodod?ecin-?12-?yl]?-?, rel-
- 英文别名:
- 中文名:
- 化合物 T10607
- 中文别名:
- 化合物 T10607
- CBNumber:
- CB78242447
- 分子式:
- C30H35N3O4
- 分子量:
- 501.62
- MOL File:
- 2446154-91-0.mol
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化合物 T10607化学性质
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沸点:
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626.0±55.0 °C(Predicted)
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密度:
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1.21±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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12.41±0.70(Predicted)
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化合物 T10607性质、用途与生产工艺
BRD5631 是一种自噬 (autophagy) 增强剂，通过与 mTOR 无关的通路来增强自噬。BRD5631 能够影响先前与自噬相关的几种细胞疾病表型，包括蛋白聚集、细胞存活、细菌复制和炎性因子的产生。
BRD5631 (10 μM, 48 hours) leads to increased levels of LC3-II in HeLa cells. BRD5631 stimulates formation of new autophagosomes, which is consistent with its ability to increase numbers of autolysosomes in the mCherry-GFP-LC3 assay.
BRD5631 does not enhance autophagy by directly inhibiting mTOR or the mTOR signaling pathway. BRD5631 suppressed IL-1β secretion in an autophagy-dependent manner.
Cell Viability Assay
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Cell Line:
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HeLa cells.
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Concentration:
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10 μM.
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Incubation Time:
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48 hours.
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Result:
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Led to increased levels of LC3-II.
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化合物 T10607
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