BAX(小鼠来源抗体)

BAX(小鼠来源抗体)性质、用途与生产工艺

描述

BCL2-associated X Protein (BAX) Mouse anti-Human Monoclonal Antibody

宿主

Mouse

克隆性

Monoclonal

种属反应性

Human, Monkey, Mouse, Rat

偶联性

Unconjugated

制备

Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse BAX, and purified by antigen affinity chromatography.

验证的应用

IHC - Paraffin (10 - 12 ug/ml), Western blot, Immunoprecipitation

品牌示例

LSBio:IHCPlus™ Monoclonal Mouse anti‑Human BCL2 / Bcl‑2 Antibody (clone 11C5, IHC, WB) LS‑B7085

Bcl-2 antibody LS-B7085 is an unconjugated mouse monoclonal antibody to human Bcl-2 (BCL2). Validated for ELISA, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.

背景

BCL2 associated X (BAX) is traditionally thought to be regulated by anti-apoptotic BCL-2 family members. BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix alpha5 from alpha6 - the 'latch' from the 'core' domain - among other conformational changes. BCL-2-associated X (BAX) protein acts as a gatekeeper in regulating mitochondria-dependent apoptosis. Under cellular stress, BAX becomes activated and transforms into a lethal oligomer that causes mitochondrial outer membrane permeabilization (MOMP).

简介

BAX(小鼠来源抗体)以人工合成的Bax氨基端(Amino-terminal)的一段多肽为抗原制备而成的抗Bax小鼠单克隆抗体。克隆号为6A7(Clone6A7)，是应用最广的Bax抗体。抗体类型为Mouse IgG1。

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BAX(小鼠来源抗体) 相关搜索:

• 小鼠抗人和大、小鼠、牛、犬、猴 Bax 多克隆抗体
• BAX(小鼠来源抗体)
• Mouse Anti-Bax (Bcl-2 Assaciated X Bcl-2 Assaciated X protein)
• Mouse Anti-Bax （Bcl-2 Assaciated X protein）