奈多罗米钠
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- CAS号:
- 69049-74-7
- 英文名:
- NEDOCROMIL SODIUM
- 英文别名:
- Tayled;Tilade;Alocril;Tilarin;Unii-et8if4ks1t;Nedocromil sodium;NEDOCROMIL DISODIUM SALT;NEDOCROMIL SODIUM###Nedocromil;Sodium 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylate;4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylicacid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, sodium salt
- 中文名:
- 奈多罗米钠
- 中文别名:
- 奈多罗米钠;化合物 T19472;9-乙基-4,6-二氧代-10-丙基-6,9-二氢-4H-吡喃并[3,2-G]喹啉-2,8-二羧酸二钠盐
- CBNumber:
- CB81011490
- 分子式:
- C19H18NNaO7
- 分子量:
- 395.34
- MOL File:
- 69049-74-7.mol
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奈多罗米钠化学性质
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储存条件:
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Inert atmosphere,2-8°C
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溶解度:
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H2O: soluble20mg/mL, clear
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形态:
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powder
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颜色:
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, white to beige to brown
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奈多罗米钠性质、用途与生产工艺
奈多罗米钠于1997年在美国被批准,开发公司是Phone Poulenc Rorer,由于是一家小型研发公司,并没有将该产品引进到中国,目前该产品已经撤市。
本类药物包括炎症细胞膜稳定剂,如色甘酸钠,奈多罗米钠以及H1受体阻断剂如酮替芬,白三烯药阻断药半胱氨酰白三烯等;通过抑制免疫球蛋白E介导的肥大细胞释放介质和对抑制巨噬细胞、嗜酸性粒细胞、单核细胞等炎症细胞的活性发挥抗过敏作用和轻度的抗炎作用。其平喘作用起效较慢,不宜用于哮喘急性发作期的治疗,临床上主要用于预防哮喘的发作。
Nedocromil sodium 抑制多种介质的作用或形成,包括组胺,白三烯 C4 (LTC4) 和前列腺素 D2 (PGD2)。
Nedocromil inhibits the release of histamine, LTC
4
, and PGD
2
from mast cells challenged with antigen (with IC
30
values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC
30
values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively).
Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function.
奈多罗米钠
上下游产品信息
上游原料
下游产品
奈多罗米钠
生产厂家
全球有 45家供应商
奈多罗米钠国内生产厂家
69049-74-7, 奈多罗米钠 相关搜索:
- API
- 黄金产品
- 原料药标样
- C19H15NO72Na
- C19H15NNa2O7
- 化合物 T19472
- 9-乙基-4,6-二氧代-10-丙基-6,9-二氢-4H-吡喃并[3,2-G]喹啉-2,8-二羧酸二钠盐
- 奈多罗米钠
- 69049-74-7
- Sodium 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylate
- NEDOCROMIL SODIUM###Nedocromil
- 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylicacid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, sodium salt (1:2)
- 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylicacid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, sodium salt
- Tilarin
- Tayled
- Unii-et8if4ks1t
- Tilade
- Alocril
- 4H-Pyrano(3,2-G)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt
- Nedocromil sodium
- [9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline]-2,8-dicarboxylic acid disodium salt
- NEDOCROMIL DISODIUM SALT