6-甲氧基-7-羟基喹唑啉-4-酮
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- CAS号:
- 162012-72-8
- 英文名:
- 6-METHOXY-7-HYDROXYQUINAZOLIN-4-ONE
- 英文别名:
- 7-hydroxy-6-methoxyquinazolin-4(3H)-one;7-Hydroxy-6-Methoxy-3,4-d...;6-METHOXY-7-HYDROXYQUINAZOLIN-4-ONE;6-Methoxy-7-Hydroxyquinazoline-4-One;6-methoxy-7-hydydroxyquinazoline-4-one;7-Hydroxy-6-methoxy-3H-quinazolin-4-one;7-hydroxy-6-methoxy-4(3H)-Quinazolinone;7-hydroxy-6-methoxyquinazolin-4(1H)-one;7-hydroxy-6-methoxy-1H-quinazolin-4-one;4(3H)-Quinazolinone,7-hydroxy-6-methoxy-
- 中文名:
- 6-甲氧基-7-羟基喹唑啉-4-酮
- 中文别名:
- 凡德中间体;7-羟基-6-甲氧基喹唑啉-4-酮;6-甲氧基-7-羟基喹唑啉-4-酮;6-甲氧基-7-羟基喹唑啉-4-酮 1G;6-甲氧基-7-羟基-3H-喹唑啉-4-酮;7-羟基-6-甲氧基-3,4-二氢喹唑啉-4-酮;7-羟基-6-甲氧基-3,4-二氢喹唑啉-4-基
- CBNumber:
- CB8122449
- 分子式:
- C9H8N2O3
- 分子量:
- 192.17
- MOL File:
- 162012-72-8.mol
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6-甲氧基-7-羟基喹唑啉-4-酮化学性质
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熔点:
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>255oC (dec.)
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沸点:
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420.0±55.0 °C(Predicted)
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO (Slightly, Heated), Methanol (Slightly, Heated)
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酸度系数(pKa):
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8.07±0.20(Predicted)
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形态:
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Solid
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颜色:
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Light Beige
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6-甲氧基-7-羟基喹唑啉-4-酮性质、用途与生产工艺
6-甲氧基-7-羟基喹唑啉-4-酮是一种医药中间体，用于制备吉非替尼。吉非替尼(Gefitinib)，化学名称为4-(3-氯-4-氟苯胺基)-7-甲氧基-6-(3-吗啉基丙氧基)喹唑啉，是由阿斯利康(AstraZeneca)公司开发的一种蛋白酪氨酸激酶抑制剂。
6-甲氧基-7-羟基喹唑啉-4-酮为酮类有机物，可用作医药中间体。
称取2-碘(溴)-4-甲氧基-5-羟基苯腈1mmol，甲脒盐酸盐1.5mmol在10mL水相中，加入CuI催化剂0.1mmol，碱K2CO33mmol，80℃微波加热回流0.5h，微波功率150W。反应结束后冷却至室温，过滤得固体粉末。
6-甲氧基-7-羟基喹唑啉-4-酮
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | XW0216201272802 | 6-甲氧基-7-羟基喹唑啉-4-酮
7-Hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one | | 1g | 49元 |
| 2024/04/30 | XW0216201272805 | 6-甲氧基-7-羟基喹唑啉-4-酮
7-Hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one | | 25g | 752元 |
162012-72-8, 6-甲氧基-7-羟基喹唑啉-4-酮 相关搜索:
- 高端化学
- 菲啰啉 喹啉 异喹啉
- 医药中间体
- 7-羟基-6-甲氧基-3,4-二氢喹唑啉-4-酮
- 6-甲氧基-7-羟基-3H-喹唑啉-4-酮
- 7-羟基-6-甲氧基-3,4-二氢喹唑啉-4-基
- 凡德中间体
- 7-羟基-6-甲氧基喹唑啉-4-酮
- 6-甲氧基-7-羟基喹唑啉-4-酮
- 6-甲氧基-7-羟基喹唑啉-4-酮 1G
- 162012-72-8
- 7-hydroxy-6-methoxyquinazolin-4(3H)-one
- 7-hydroxy-6-methoxy-1H-quinazolin-4-one
- 4(3H)-Quinazolinone,7-hydroxy-6-methoxy-
- 7-Hydroxy-6-methoxy-3H-quinazolin-4-one
- 7-hydroxy-6-methoxy-4(3H)-Quinazolinone
- 7-hydroxy-6-methoxyquinazolin-4(1H)-one
- 6-methoxy-7-hydydroxyquinazoline-4-one
- 6-Methoxy-7-Hydroxyquinazoline-4-One
- 7-Hydroxy-6-Methoxy-3,4-dihydroquinazolin-4-one
- 7-Hydroxy-6-Methoxy-3,4-d...
- 6-METHOXY-7-HYDROXYQUINAZOLIN-4-ONE