绿僵菌素B, 来源于绿僵菌属
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- CAS号:
- 2503-26-6
- 英文名:
- destruxin B
- 英文别名:
- destruxin B;Destruxin B from Metarhizium anisopliae;Destruxin B, from Metarrhizium anisopliae;Destruxin B, 97.5%, from Metarrhizium anisopliae;N-[N-[(R)-2-Hydroxy-4-methyl-1-oxopentyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone;Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl;Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl];N-[N-[(2R)-1-Oxo-2-hydroxy-4-methylpentyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone
- 中文名:
- 绿僵菌素B, 来源于绿僵菌属
- 中文别名:
- 绿僵菌素B;腐败菌素B;黑僵菌素 B;绿僵菌素B, 来源于绿僵菌属
- CBNumber:
- CB81304031
- 分子式:
- C30H51N5O7
- 分子量:
- 593.761
- MOL File:
- 2503-26-6.mol
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绿僵菌素B, 来源于绿僵菌属化学性质
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熔点:
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234 °C
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沸点:
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875.0±65.0 °C(Predicted)
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密度:
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1.17±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO (up to 10 mg/ml)
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形态:
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solid
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酸度系数(pKa):
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13.54±0.70(Predicted)
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颜色:
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White
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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绿僵菌素B, 来源于绿僵菌属性质、用途与生产工艺
Destruxin B 是从昆虫病原真菌中分离的绿僵菌 (Metarhizium anisopliae),是一种具有杀虫和抗癌活性的环肽。 Destruxin B 通过 Bcl-2 家族依赖的线粒体途径在人类非小细胞肺癌细胞中诱导细胞凋亡。Destruxin B 显著激活 caspase-3,并在体外和体内通过 caspase 介导的细胞凋亡减少肿瘤细胞增殖。
Destruxin B (1-30 μM; 48 hours) inhibits cell proliferation of H1299 cells and A549 cells, with IC
50
s of 4.1 μM and 4.9 μM, respectively.
Activation of mitochondria-dependent caspase cascade plays an important role in Destruxin B (1-30 μM; 48 hours) induced apoptotic cell death in A549 cells.
Destruxin B (1.25-20.00 μM; 72 hours) treatment significantly inhibits HT-29 human colorectal cancer cells viability in time- and dose-dependent manners.
Destruxin B (10 or 20 μM; 12 and 24 hours) treatment markedly increases levels of the proapoptotic protein PUMA and reduces levels of antiapoptotic proteins Mcl-1 of A549 cells in a concentration- and time-dependent manner .
Cell Proliferation Assay
Cell Line:
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H1299 cells
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Concentration:
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1, 5, 10, 20, 30 μM
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Incubation Time:
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48 hours
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Result:
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Inhibited H1299 cells proliferation of H1299 cells with an IC
50
of 4.1 μM.
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Apoptosis Analysis
Cell Line:
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Lung adenocarcinoma A549 cells
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Concentration:
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1, 5, 10, 20, 30 μM
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Incubation Time:
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48 hours
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Result:
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Induces caspase-dependent Lung adenocarcinoma A549 cells death.
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Cell Viability Assay
Cell Line:
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HT-29 human colorectal cancer cells
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Concentration:
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1.25, 2.50, 5.00, 10.00 and 20.00 μM
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Incubation Time:
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72 hours
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Result:
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The IC
50
s at 24 h, 48 h and 72h were determined as 14.97, 2.00 and 0.67 μM, respectively.
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Western Blot Analysis
Cell Line:
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A549 cells
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Concentration:
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10 or 20 μM
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Incubation Time:
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12 and 24 hours
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Result:
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Regulates Mcl-1 and PUMA.
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Destruxin B (DB) ( injection; 0.6-15 mg/kg/day for 6 weeks) attenuates the tumor growth in time- and dose-dependent manners.
Animal Model:
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Athymic female nude mice (BALB/cAnN.Cg-Foxn1nu/CrlNarl), approximately 4-5 weeks old on arrival
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Dosage:
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Low dose (0.6 mg/kg), medium dose (3 mg/kg), high dose (15 mg/kg)
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Administration:
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Injection; daily; for 6 weeks
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Result:
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Low dose, medium dose and high dose indicated a reduction of 23.9%, 33.4% and 55.8% in mean tumor size, respectively.
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绿僵菌素B, 来源于绿僵菌属
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-N6690 | 绿僵菌素B, 来源于绿僵菌属 Destruxin B | 2503-26-6 | 1mg | 7800元 |
2023/10/26 | HY-N6690 | 绿僵菌素B, 来源于绿僵菌属 Destruxin B | 2503-26-6 | 5mg | 27500元 |
2503-26-6, 绿僵菌素B, 来源于绿僵菌属 相关搜索:
- 抑制剂
- 医药原料
- 腐败菌素B
- 黑僵菌素 B
- 绿僵菌素B
- 绿僵菌素B, 来源于绿僵菌属
- 2503-26-6
- Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl
- Destruxin B, from Metarrhizium anisopliae
- Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl]
- Destruxin B from Metarhizium anisopliae
- Destruxin B, 97.5%, from Metarrhizium anisopliae
- N-[N-[(R)-2-Hydroxy-4-methyl-1-oxopentyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone
- N-[N-[(2R)-1-Oxo-2-hydroxy-4-methylpentyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone
- destruxin B