网站主页 >> CAS数据库列表 >> (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
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- CAS号:
- 187665-65-2
- 英文名:
- (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
- 英文别名:
- PNU 142633;PNU142633,PNU 142633;(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE;1H-2-Benzopyran-6-carboxamide, 1-[2-[4-[4-(aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-, (1S)-
- 中文名:
- (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
- 中文别名:
- 化合物 T16556
- CBNumber:
- CB82454328
- 分子式:
- C24H30N4O3
- 分子量:
- 422.52
- MOL File:
- 187665-65-2.mol
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(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE化学性质
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沸点:
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652.5±55.0 °C(Predicted)
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密度:
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1?+-.0.06 g/cm3(Predicted)
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储存条件:
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Store at +4°C
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溶解度:
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Soluble to 100 mM in DMSO
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形态:
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Powder
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酸度系数(pKa):
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15.27±0.40(Predicted)
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颜色:
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White to off-white
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(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE性质、用途与生产工艺
PNU-142633 是一种高亲和力,选择性和口服活性的 5-HT1D 激动剂,对人 5-HT1D 受体和人 5-HT1B 受体的 Ki 分别为 6 nM 和 >18 000 nM。PNU-142633 具有抗偏头痛功效。
5-HT
1D
Receptor
6 nM (Ki)
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The intrinsic activity of PNU-142633 at the human 5-HT1D receptor is determined to be 70% that of 5-HT in a cytosensor cell-based assay compared with 84% for that of Sumatriptan.
PNU-142633 (0.03-1 mg/kg; intravenous injection; male Hartley guinea pigs) treatment blocks neurogenic plasma protein extravasation. And PNU-142633 fails to alter resistance in these vascular beds.
Animal Model:
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Male Hartley guinea pigs (250-300 g) stimulated with bipolar electrode
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Dosage:
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0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg
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Administration:
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Intravenous injection
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Result:
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Significantly reduced extravasation at the 0.1 and 0.3 mg/kg doses, but was without effect at the 0.03 and 1.0 mg/kg doses.
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(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-103131 | PNU-142633 | | 1 mg | 1650元 |
2024/08/19 | HY-103131 | PNU-142633 | | 10 mM * 1 mLin DMSO | 5461元 |
(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
生产厂家
187665-65-2, (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE 相关搜索:
- 化合物 T16556
- 187665-65-2
- 1H-2-Benzopyran-6-carboxamide, 1-[2-[4-[4-(aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-, (1S)-
- PNU142633,PNU 142633
- PNU 142633
- (1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE