CUDA
|
|
|
- CAS号:
- 479413-68-8
- 英文名:
- CUDA
- 英文别名:
- CUDA;CUDA Exclusive;HPTJABJPZMULFH-UHFFFAOYSA-N;Dodecanoic acid, 12-[[(cyclohexylamino)carbonyl]amino]-;PPARalpha,epoxide,Peroxisome proliferator-activated receptors,cardiovascular,Inhibitor,peroxisome,Soluble,inhibit,disease,receptor,sEH,proliferator-activated,PPAR,Epoxide Hydrolase,hypotensive,CUDA,PPARα,hydrolase,lipid-lowering
- 中文名:
- CUDA
- 中文别名:
- 卡达;化合物CUDA;12-(3-环己基脲基)十二烷酸
- CBNumber:
- CB82590750
- 分子式:
- C19H36N2O3
- 分子量:
- 340.5
- MOL File:
- 479413-68-8.mol
|
|
|
CUDA化学性质
-
沸点:
-
549.4±19.0 °C(Predicted)
-
|
-
密度:
-
1.03±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
≤1mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
-
|
-
形态:
-
crystalline solid
-
|
-
酸度系数(pKa):
-
4.78±0.10(Predicted)
-
|
-
颜色:
-
White to off-white
-
|
CUDA性质、用途与生产工艺
CUDA 是一种有效的可溶性环氧水解酶 (sEH) 抑制剂，对小鼠 sEH 和人 sEH 作用的 IC50 分别为 11.1 nM 和 112 nM。CUDA 能选择性地上调过氧化物酶体增殖激活受体 PPARalpha 的活性。CUDA 可能对心血管疾病的研究有价值。
|
PPARα
|
mouse sEH
11.1 nM (IC
50
)
|
human sEH
112 nM (IC
50
)
|
CUDA (10 μM; 18 hours) produces 6- and 3-fold increases of PPARalpha in COS-7 cells.
CUDA does not alter PPARalpha protein expression, and it competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, suggesting that it functions as a PPARalpha ligand.
Western Blot Analysis
|
Cell Line:
|
COS-7 cells
|
|
Concentration:
|
10 μM
|
|
Incubation Time:
|
18 hours
|
|
Result:
|
Activated PPARα by binding to the ligand binding domain of PPARα.
|
CUDA
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-121538 | CUDA
CUDA | 479413-68-8 | 5mg | 500元 |
| 2024/11/08 | HY-121538 | CUDA
CUDA | | 10 mM * 1 mLin DMSO | 550元 |
479413-68-8, CUDA 相关搜索:
- 抑制剂
- 小分子
- 抗体-二抗
- 12-(3-环己基脲基)十二烷酸
- 卡达
- 化合物CUDA
- 479413-68-8
- PPARalpha,epoxide,Peroxisome proliferator-activated receptors,cardiovascular,Inhibitor,peroxisome,Soluble,inhibit,disease,receptor,sEH,proliferator-activated,PPAR,Epoxide Hydrolase,hypotensive,CUDA,PPARα,hydrolase,lipid-lowering
- Dodecanoic acid, 12-[[(cyclohexylamino)carbonyl]amino]-
- HPTJABJPZMULFH-UHFFFAOYSA-N
- CUDA Exclusive
- CUDA