S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺
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- CAS号:
- 21306-65-0
- 英文名:
- NPD-123
- 英文别名:
- TPh A;NPD-123;Triphenyl compound A;S-Methyl-S-(4-benzyloxy-phenyl)-N-(p-toluolsulfonyl)-sulfimid;S-[4-(Benzyloxy)phenyl]-S-methyl-N-(p-tolylsulfonyl)-sulfilimine;S-[p-(Benzyloxy)phenyl]-S-methyl-N-(p-tolylsulfonyl)-sulfilimine;N-{[4-(Benzyloxy)phenyl](methyl)-γ4-sulfanylidene}-4-methylbenzenesulfonamide;Benzenesulfonamide, 4-methyl-N-[methyl[4-(phenylmethoxy)phenyl]-λ4-sulfanylidene]-
- 中文名:
- S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺
- 中文别名:
- S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺
- CBNumber:
- CB82628198
- 分子式:
- C21H21NO3S2
- 分子量:
- 399.53
- MOL File:
- 21306-65-0.mol
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S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺化学性质
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沸点:
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587.6±60.0 °C(Predicted)
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密度:
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1.22±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: >30mg/mL
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形态:
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white powder
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颜色:
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White
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S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺性质、用途与生产工艺
TPh A (Triphenyl Compound A) 是核蛋白 pirin 的有效抑制剂，其 Ki 值为0.6 uM。TPh A 破坏 Bcl3-pirin 复合物的形成。TPh A 可作为相关的小分子工具调控细胞内的 Pirin。
The Pirin is a nuclear protein with the nuclear factor I/CCAAT box transcription factor (NFI/CTF). Pirin proteins are highly conserved between mammals, plants, fungi, and prokaryotic organisms and are considered to belong to the cupin superfamily.TPh A (20 μM; 5 hours) reduces the amount of pirin-bound Bcl3 and inhibits the interaction between pirin and Bcl3 in HEK293T cells in a glutathione S-transferase (GST) pulldown assay (HEK293T cells are transfected with vectors that encoded bcl3-Myc and pirin-His6 for 43 h of transfection).TPh A (0-100 μM; 48 hours) does not exert any potent cytotoxic activity against many human cancer cell lines, it against MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells with IC
50
values >50 μM, and exhibits IC
50
values of 27 μM, 20 μM and 26 μM for PC3 HL60 and HT29 cells, respectively.TPhA (0-50 μM; 48 hours) inhibits cell migration in WM266-4 cells, SK-MEL-28 cell in a concentration-dependent manner.
Cell Viability Assay
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Cell Line:
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MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells
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Concentration:
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0-100 μM
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Incubation Time:
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48 hours
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Result:
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Did not exert any potent cytotoxic activity against many human cancer cell lines.
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S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-14454 | S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺
TPh A | 21306-65-0 | 5mg | 1000元 |
| 2024/04/30 | HY-14454 | S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺
TPh A | | 10 mM * 1 mLin DMSO | 1100元 |
S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺
生产厂家
21306-65-0, S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺 相关搜索:
- S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺
- 21306-65-0
- Benzenesulfonamide, 4-methyl-N-[methyl[4-(phenylmethoxy)phenyl]-λ4-sulfanylidene]-
- S-Methyl-S-(4-benzyloxy-phenyl)-N-(p-toluolsulfonyl)-sulfimid
- Triphenyl compound A
- S-[p-(Benzyloxy)phenyl]-S-methyl-N-(p-tolylsulfonyl)-sulfilimine
- N-{[4-(Benzyloxy)phenyl](methyl)-γ4-sulfanylidene}-4-methylbenzenesulfonamide
- S-[4-(Benzyloxy)phenyl]-S-methyl-N-(p-tolylsulfonyl)-sulfilimine
- TPh A
- NPD-123