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3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
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- CAS号:
- 33985-68-1
- 英文名:
- 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
- 英文别名:
- C-DIM5;DIM-C-pPhOMe;DIM C pPhOMe;DIM-C-pPhOCH3;DIM-C-pPhOCH3(C-DIM5);DIM-C-pPhOCH3 >=98% (HPLC);Bis(1H-indol-3-yl)(4-methoxyphenyl)]methane;1,1-bis(3′-Indolyl)-1-(p-methoxyphenyl)methane;3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole);3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
- 中文名:
- 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
- 中文别名:
- 化合物DIM-C-PPHOCH3;DIM-C-PPHOCH3,NUR77激动剂;3,3'-((4-甲氧基苯基)亚甲基)双(1H-吲哚);3,3'-((4-甲氧基苯基)亚甲基)双(1H-吲哚)
- CBNumber:
- CB82682260
- 分子式:
- C24H20N2O
- 分子量:
- 352.43
- MOL File:
- 33985-68-1.mol
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3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)化学性质
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熔点:
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187-189 °C
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沸点:
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592.7±50.0 °C(Predicted)
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密度:
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1.251±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥30mg/mL
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形态:
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powder
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酸度系数(pKa):
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16.63±0.30(Predicted)
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颜色:
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off-white to light yellow
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3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)性质、用途与生产工艺
C-DIM5 (DIM-C-pPhOCH3) 是一种孤儿核受体 Nur77 (Nerve growth factor-induced Bα (NGFI-Bα)/nuclear receptor 4A1 (NR4A1)) 的激动剂。C-DIM5 (DIM-C-pPhOCH3) 可在RKO结肠癌细胞中降低存活率并诱导凋亡。
DIM-C-pPhOCH
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decreases survival and induces apoptosis in RKO colon cancer cells, and this is accompanied by induction of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) protein. DIM-C-pPhOCH
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also induces Nur77-independent apoptosis. DIM-C-pPhOCH
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(10 μM) inhibits cell growth after treatment for 24, 48, or 72 h, and the maximum inhibitory response is observed after 72 h, where there is considerable cell detachment and dead cells. The growth-inhibitory effects observed for DIM-C-pPhOCH
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after 72 h are also accompanied by several markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8. PARP cleavage is also observed after treatment of RKO cells for 48 h with DIM-C-pPhOCH
3
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DIM-C-pPhOCH
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(25 mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH
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(25 mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH
3
significantly decreases tumor volumes and final tumor weights compared with corn oil controls.
3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-111492 | 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) DIM-C-pPhOCH3 | 33985-68-1 | 5mg | 800元 |
2024/04/30 | S0149 | 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) C-DIM5 | 33985-68-1 | 5mg | 874.46元 |
3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
生产厂家
33985-68-1, 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) 相关搜索:
- 化工试剂
- 药靶配体
- 吲哚类
- 3,3'-((4-甲氧基苯基)亚甲基)双(1H-吲哚)
- DIM-C-PPHOCH3,NUR77激动剂
- 3,3'-((4-甲氧基苯基)亚甲基)双(1H-吲哚)
- 化合物DIM-C-PPHOCH3
- 33985-68-1
- 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
- DIM-C-pPhOMe
- DIM C pPhOMe
- Inhibitor,DIM-C-pPhOCH-3,DIM C pPhOCH3,DIMCpPhOCH3,inhibit
- C-DIM5
- DIM-C-pPhOCH3(C-DIM5)
- 1H-Indole, 3,3'-[(4-methoxyphenyl)methylene]bis-
- DIM-C-pPhOCH3 >=98% (HPLC)
- Bis(1H-indol-3-yl)(4-methoxyphenyl)]methane
- 1,1-bis(3′-Indolyl)-1-(p-methoxyphenyl)methane
- 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
- DIM-C-pPhOCH3