PU-02; PU02
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- CAS号:
- 313984-77-9
- 英文名:
- 6-[(1-NaphthalenylMethyl)thio]-9H-purine
- 英文别名:
- PU 02;PU-02; PU02;6-[(1-NaphthalenylMethyl)thio]-9H-purine;6-((Naphthalen-1-ylmethyl)thio)-7H-purine;9H-Purine, 6-[(1-naphthalenylmethyl)thio]-;6-(Naphthalen-1-ylmethylsulfanyl)-7H-purine;5-HT Receptor,cyclin B1,cyclinD1,Inhibitor,Apoptosis,Serotonin Receptor,PU02,PU 02,HepG2,CDK4,5-hydroxytryptamine Receptor,inhibit
- 中文名:
- PU-02; PU02
- 中文别名:
- 化合物PU-02;PU 02,5-HT3受体的负变构调节剂;6-[(1-萘基甲基)硫基]-9H-嘌呤;6-((萘-1-基甲基)硫基)-7H-嘌呤
- CBNumber:
- CB82686026
- 分子式:
- C16H12N4S
- 分子量:
- 292.36
- MOL File:
- 313984-77-9.mol
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PU-02; PU02化学性质
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储存条件:
-
2-8°C
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-
溶解度:
-
Soluble to 100 mM in DMSO
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形态:
-
Powder
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-
颜色:
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White to off-white
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PU-02; PU02性质、用途与生产工艺
PU02 是 6-MP (HY-13677) 的一个衍生物,是 5-HT3 受体的负变构调节剂,其在 HEK293 细胞测得的转染 5-HT3A 和 5-HT3AB 受体后的 IC50 值分别为 0.36 和 0.73 μM。
5-HT
3A
Receptor
0.36 μM (IC
50
)
|
5-HT
3
AB
0.73 μM (IC
50
)
|
PU02 (NMMP) (0-200 μM) leads to a steady decrease in cell viability of HepG2 cells (IC
50
=48.585 μM). PU02 (NMMP) shows less toxicity on L02 cells than did 6-MP after 48 h of treatment.
PU02 (NMMP) at 6.25 or 25 μM exhibits inhibitory effects on the viability of the tested cell lines, including SMMC-7721, MDA-MB-231, RKO and HCT-8 cells.
PU02 (NMMP) induces cell cycle arrest at the G2/M phase. PU02 (NMMP) downregulats the expression of cyclin B1/D1 and CDK4 in a time-dependent manner in HepG2 cells,but the expression of cyclin E is not affected.
PU02 (NMMP)-treated cells exhibits a significant increase in caspase-3 cleavage, suggesting enhanced apoptotic activity.
Apoptosis Analysis
Cell Line:
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HepG2 cells.
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Concentration:
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6.26, 12.5, 25, 50 μM.
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Incubation Time:
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6, 12, 24, 36 h.
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Result:
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Induced mitochondria-dependent apoptosis.
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PU-02; PU02
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-103118 | PU02 | | 5 mg | 700元 |
2024/08/19 | HY-103118 | PU-02; PU02 PU02 | 313984-77-9 | 10mM * 1mLin DMSO | 770元 |
313984-77-9, PU-02; PU02 相关搜索:
- 合成材料中间体
- 药靶配体
- PU 02,5-HT3受体的负变构调节剂
- 6-[(1-萘基甲基)硫基]-9H-嘌呤
- 化合物PU-02
- 6-((萘-1-基甲基)硫基)-7H-嘌呤
- 313984-77-9
- 5-HT Receptor,cyclin B1,cyclinD1,Inhibitor,Apoptosis,Serotonin Receptor,PU02,PU 02,HepG2,CDK4,5-hydroxytryptamine Receptor,inhibit
- 9H-Purine, 6-[(1-naphthalenylmethyl)thio]-
- PU-02; PU02
- 6-(Naphthalen-1-ylmethylsulfanyl)-7H-purine
- 6-((Naphthalen-1-ylmethyl)thio)-7H-purine
- PU 02
- 6-[(1-NaphthalenylMethyl)thio]-9H-purine