5MG
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- CAS号:
- 2070015-00-6
- 英文名:
- GNE-7915 (tosylate)
- 英文别名:
- CS-1278;GNE-7915 (tosylate);GNE-7915 tosylate
(GNE7915 tosylate
- 中文名:
- 5MG
- 中文别名:
- CBNumber:
- CB82705084
- 分子式:
- C26H29F4N5O6S
- 分子量:
- 615.6
- MOL File:
- 2070015-00-6.mol
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5MG化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: ≥ 50 mg/mL (81.22 mM); Water: < 0.1 mg/mL (insoluble)
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形态:
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Solid
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颜色:
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White to off-white
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5MG性质、用途与生产工艺
GNE-7915 tosylate是高效选择性,可渗透大脑的LRRK2抑制剂,IC50值为9 nM。
Maintaining the methoxy/fluoro arrangement at C-2′/C-5′ and varying aminoalkyl R1 substitution resultes in single-digit nanomolar LRRK2 cellular activities for GNE-7915 and compound 19. Expanded Invitrogen kinase profiling (187 kinases) at 0.1 μM for both GNE-7915 (100-fold over LRRK2 Ki) and 19 (250-fold over LRRK2 Ki) resultes in only TTK showing greater than 50% inhibition. Selectivity profiling using the DiscoverX KinomeScan55 competitive binding assay panel, which includes 392 unique kinases, is also performed for GNE-7915 at 0.1 μM. Binding of >50% probe displacement is detected for 10 kinases and of >65% for only LRRK2, TTK, and ALK, further supporting the excellent LRRK2 selectivity for GNE-7915. Cerep receptor profiling, including expanded brain panels, suggestes that GNE-7915 and 19 only inhibite 5-HT
2B
with >70% inhibition at 10 μM. GNE-7915 and 19 are confirmed to be moderately potent 5-HT
2B
antagonists in vitro functional assays.
5MG
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-18163A | GNE-7915 tosylate | 2070015-00-6 | 5 mg | 500元 |
2024/08/19 | HY-18163A | GNE-7915 tosylate | 2070015-00-6 | 10mM * 1mLin DMSO | 677元 |
2070015-00-6, 5MG 相关搜索:
- 2070015-00-6
- CS-1278
- GNE-7915 tosylate
(GNE7915 tosylate
- GNE-7915 (tosylate)