FESTINAVIR
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- CAS号:
- 634907-30-5
- 英文名:
- Censavudine
- 英文别名:
- OBP601;4'-Ed4T;OBP 601;OBP-601;BMS 986001;Festinavir;Censavudine;2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine;Thymidine, 2',3'-didehydro-3'-deoxy-4'-ethynyl-
- 中文名:
- FESTINAVIR
- 中文别名:
- 化合物 T30791;2′,3′-二脱氢-3′-脱氧-4′-乙炔基胸苷
- CBNumber:
- CB82717753
- 分子式:
- C12H12N2O4
- 分子量:
- 248.23
- MOL File:
- 634907-30-5.mol
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FESTINAVIR化学性质
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熔点:
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207-209℃
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密度:
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1.42±0.1 g/cm3(Predicted)
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储存条件:
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4°C, away from moisture
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溶解度:
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DMSO : 52 mg/mL (209.48 mM; Need ultrasonic)
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酸度系数(pKa):
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9.47±0.10(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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FESTINAVIR性质、用途与生产工艺
Censavudine (OBP-601; BMS-986001)，一种核苷类似物，是一种核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂。Censavudine 是一种有效的 HIV 抑制剂，对 HIV-2 和 HIV-1 的 EC50 范围分别为 30-81 nM 和 450-890 nM。
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HIV-2
30-81 nM (EC
50
)
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HIV-1
450-890 nM (IC
50
)
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BMS-986001 shows greater activity against HIV-2
ROD9
than against HIV-1
NL4-3
; the mean EC
50
s for BMS-986001 are 74 nM for HIV-2
ROD9
and 890 nM for HIV-1
NL4-3
in the single-cycle assay. HIV-2
ROD9
also showes greater sensitivity to BMS-986001 in 4-day infections of an immortalized T cell line (CEMss), with the mean EC
50
for HIV-2
ROD9
(EC
50
of 0.14 nM) being 30-fold lower than that for HIV-1
NL4-3
(EC
50
of 4.2 nM).
BMS-986001 also exhibits full activity against HIV-2 variants whose genomes encoded the single amino acid changes K65R and Q151M in reverse transcriptase.
The pharmacokinetic parameters of Censavudine (BMS-986001; 100-750 mg/kg) generated from the dried blood spot (DBS) assay and the plasma assay is compared. The ratios of the AUC
(0-24 h)
and C
max
for BMS-986001 in DBS compared to those in plasma are consistent at 0.83-0.91 and 0.81-0.97, respectively, across all dose groups in rats. The T
max
in rat DBS and plasma are also consistent at about 1 h.
FESTINAVIR
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-16776 | Censavudine | | 1 mg | 2480元 |
| 2024/08/19 | HY-16776 | FESTINAVIR
Censavudine | 634907-30-5 | 5 mg | 6200元 |
634907-30-5, FESTINAVIR 相关搜索:
- 2′,3′-二脱氢-3′-脱氧-4′-乙炔基胸苷
- 化合物 T30791
- 634907-30-5
- OBP-601
- OBP601
- OBP 601
- Thymidine, 2',3'-didehydro-3'-deoxy-4'-ethynyl-
- Festinavir
- Censavudine
- BMS 986001
- 4'-Ed4T
- 2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine